Literature DB >> 18830679

Three-component one-pot synthesis of 4,6-diarylpyrimidin- 2(1H)-ones under solvent-free conditions in the presence of sulfamic acid as a green and reusable catalyst.

Majid M Heravi1, Leila Ranjbar, Fatemeh Derikvand, Behnoush Alimadadi.   

Abstract

A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones and related heterocycles is described. The condensation of acetophenone derivatives, aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimidinones in moderate to excellent yields. The scope and limitations of this method are described.

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Year:  2008        PMID： 18830679     DOI： 10.1007/s11030-008-9089-5

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  7 in total

Review 1.  The application of multi-component reactions in drug discovery.

Authors:  Lutz Weber
Journal:  Curr Med Chem       Date:  2002-12       Impact factor: 4.530

Review 2.  "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Authors:  Christopher Hulme; Vijay Gore
Journal:  Curr Med Chem       Date:  2003-01       Impact factor: 4.530

3.  6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase.

Authors:  Sara Bartolini; Antonello Mai; Marino Artico; Nicola Paesano; Dante Rotili; Corrado Spadafora; Gianluca Sbardella
Journal:  J Med Chem       Date:  2005-11-03       Impact factor: 7.446

4.  An efficient synthesis of 3,4-dihydropyrimidin-2-ones catalyzed by NH2SO3H under ultrasound irradiation.

Authors:  Ji-Tai Li; Jun-Fen Han; Jin-Hui Yang; Tong-Shuang Li
Journal:  Ultrason Sonochem       Date:  2003-05       Impact factor: 7.491

5.  Oxidative aromatization of Hantzsch 1,4-dihydropyridines in the presence of mixed-addenda vanadomolybdophosphate heteropolyacid, H6PMo9V3O40.

Authors:  Majid M Heravi; Fatemeh Derikvand; Shahla Hassan-Pour; Khadijeh Bakhtiari; Fatemeh F Bamoharram; Hossein A Oskooie
Journal:  Bioorg Med Chem Lett       Date:  2007-04-06       Impact factor: 2.823

6.  Mechanism of antitumor action of pyrimidinones in the treatment of B16 melanoma and P388 leukemia.

Authors:  L H Li; T L Wallace; K A Richard; D E Tracey
Journal:  Cancer Res       Date:  1985-02       Impact factor: 12.701

7.  Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.

Authors:  Satoshi Sasaki; Nobuo Cho; Yoshi Nara; Masataka Harada; Satoshi Endo; Nobuhiro Suzuki; Shuichi Furuya; Masahiko Fujino
Journal:  J Med Chem       Date:  2003-01-02       Impact factor: 7.446
  7 in total
  1 in total

1.  One-pot synthesis of tetrazolo[1,5-a]pyrimidines under solvent-free conditions.

Authors:  Ramin Ghorbani-Vaghei; Zahra Toghraei-Semiromi; Mostafa Amiri; Rahman Karimi-Nami
Journal:  Mol Divers       Date:  2013-03-30       Impact factor: 2.943
  1 in total

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