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Literature DB >> 188297

Krabbe's disease. A light and electron microscopic study.

S S Schochet, W F McCormick, G F Powell.

Abstract

Ultrastructural studies of brain and sural nerve biopsy specimens from a patient with Krabbe's disease disclosed periodically constricted or twisted tubules in addition to the more abundant and characteristic crystalloid and prismatic structures within macrophages. It is suggested that the twisted tubules may result from the intracellular accumulation of lactosyl ceramide. Familiarity with these unusual tubular structures is of practical as well as theoretical importance since they may be encountered in brain and peripheral nerve biopsy specimens obtained for the morphological diagnosis of Krabbe's disease.

Entities: Chemical Disease Species

Mesh：

Year: 1976 PMID： 188297 DOI： 10.1007/bf00685277

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

22 in total

1. Globid leukodystrophy. II. Ultrastructure and chemical pathology.

Authors: M J Malone; M Szöke; D A Davis
Journal: Arch Neurol Date: 1975-09

2. Globoid cell leukodystrophy (Krabbe's disease): morphological and biochemical studies.

Authors: J M Andrews; P A Cancilla; J Grippo; J H Menkes
Journal: Neurology Date: 1971-04 Impact factor: 9.910

3. A histochemical and electron microscopic study of Gaucher cells.

Authors: R G Hibbs; V J Ferrans; P R Cipriano; K J Tardiff
Journal: Arch Pathol Date: 1970-02

4. Experimental studies on the pathogenesis of leucodystrophies. I. The effect of intracerebrally injected sphingolipids in the rat's brain.

Authors: Y Olsson; P Sourander; L Svennerholm
Journal: Acta Neuropathol Date: 1966-03-04 Impact factor: 17.088

5. Further observations on the fine structure of globoid leukodystrophy. Peripheral neuropathy and optic nerve involvement.

Authors: E J Yunis; R E Lee
Journal: Hum Pathol Date: 1972-09 Impact factor: 3.466

6. Peripheral neuropathy in globoid cel leucodystrophy (morbus Krabbe).

Authors: P Sourander; Y Olsson
Journal: Acta Neuropathol Date: 1968-07-08 Impact factor: 17.088

7. Quantitative and qualitative study of sural nerve biopsies in Krabbe's disease.

Authors: W W Schlaepfer; A L Prensky
Journal: Acta Neuropathol Date: 1972 Impact factor: 17.088

8. Tubules of globoid leukodystrophy: a right-handed helix.

Authors: E J Yunis; R E Lee
Journal: Science Date: 1970-07-03 Impact factor: 47.728

9. [The origin of multinucleated giant cells in experimentally induced and spontaneous Krabbe's disease (globoid cell leukodystrophy) (author's transl)].

Authors: M Oehmichen; H Gräuninger
Journal: Beitr Pathol Date: 1974

7. Murine globoid cell leukodystrophy (the twitcher mouse). The presence of characteristic inclusions in the kidney and lymph nodes.

Authors: H Takahashi; H Igisu; K Suzuki; K Suzuki
Journal: Am J Pathol Date: 1983-08 Impact factor: 4.307

7 in total

Krabbe's disease. A light and electron microscopic study.

1. Globid leukodystrophy. II. Ultrastructure and chemical pathology.

2. Globoid cell leukodystrophy (Krabbe's disease): morphological and biochemical studies.

3. A histochemical and electron microscopic study of Gaucher cells.

4. Experimental studies on the pathogenesis of leucodystrophies. I. The effect of intracerebrally injected sphingolipids in the rat's brain.

5. Further observations on the fine structure of globoid leukodystrophy. Peripheral neuropathy and optic nerve involvement.

6. Peripheral neuropathy in globoid cel leucodystrophy (morbus Krabbe).

7. Quantitative and qualitative study of sural nerve biopsies in Krabbe's disease.

8. Tubules of globoid leukodystrophy: a right-handed helix.

9. [The origin of multinucleated giant cells in experimentally induced and spontaneous Krabbe's disease (globoid cell leukodystrophy) (author's transl)].

10. Cytoplasmic inclusions in human globoid cell leukodystrophy. Krabbe's disease.

Review 1. Basic findings and current developments in sphingolipidoses.

2. Sub-plasmalemmal linear density: a common structure in globoid cells and mesenchymal cells.

Review 3. Progress in investigations of sphingolipidoses.

4. Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.

5. Globoid cell leukodystrophy: specialized contact of globoid cell with astrocyte in the brain of twitcher mouse.

6. Demyelination in the spinal cord of murine globoid cell leukodystrophy (the twitcher mouse).

7. Murine globoid cell leukodystrophy (the twitcher mouse). The presence of characteristic inclusions in the kidney and lymph nodes.