Literature DB >> 18829634

Hydroxychloroquine retinopathy screening.

A E Semmer1, M S Lee, A R Harrison, T W Olsen.   

Abstract

AIM: To compare current hydroxychloroquine retinopathy screening practices with the published 2002 American Academy of Ophthalmology (AAO) Preferred Practice Patterns (PPP).
METHODS: A multiple-choice survey was distributed to 105 ophthalmologists to assess current screening practices and knowledge of patient risk factors. Results were compared with the PPP guidelines. A cost analysis of the PPP and survey paradigms was conducted.
RESULTS: Sixty-seven (64%) of 105 surveys were completed. The majority (90%) of physicians screen for hydroxychloroquine retinopathy with either central automated threshold perimetry or Amsler grid as recommended by the PPP. Most survey respondents could not correctly identify the evidence-based risk factors. The majority screen more frequently than recommended: 87% screen high-risk patients and 94% screen low-risk patients more frequently than recommended in the PPP. The increased screening frequency of low-risk patients translates into an excess of $44 million in the first 5 years of therapy. If all patients were screened using exact PPP paradigm, savings could exceed $150 million every 10 years.
CONCLUSIONS: Ophthalmologists currently screen for hydroxychloroquine retinopathy correctly; however, their lack of familiarity with evidence-based guidelines may result in excessive follow-up. Increasing awareness and implementation of the PPP could potentially reduce hydroxychloroquine retinopathy screening costs significantly.

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Year:  2008        PMID: 18829634      PMCID: PMC4397565          DOI: 10.1136/bjo.2008.144402

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  15 in total

1.  Hydroxychloroquine and visual screening in a rheumatology outpatient clinic.

Authors:  D J Grierson
Journal:  Ann Rheum Dis       Date:  1997-03       Impact factor: 19.103

2.  Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: a report by the American Academy of Ophthalmology.

Authors:  Michael F Marmor; Ronald E Carr; Michael Easterbrook; Ayad A Farjo; William F Mieler
Journal:  Ophthalmology       Date:  2002-07       Impact factor: 12.079

3.  Retinopathy following chloroquine therapy.

Authors:  H E HOBBS; A SORSBY; A FREEDMAN
Journal:  Lancet       Date:  1959-10-03       Impact factor: 79.321

4.  Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice.

Authors:  G D Levy; S J Munz; J Paschal; H B Cohen; K J Pince; T Peterson
Journal:  Arthritis Rheum       Date:  1997-08

5.  Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern(®) Guidelines.

Authors:  Robert S Feder; Timothy W Olsen; Bruce E Prum; C Gail Summers; Randall J Olson; Ruth D Williams; David C Musch
Journal:  Ophthalmology       Date:  2015-11-12       Impact factor: 12.079

6.  The dilemma of hydroxychloroquine screening: new information from the multifocal ERG.

Authors:  Michael F Marmor
Journal:  Am J Ophthalmol       Date:  2005-11       Impact factor: 5.258

Review 7.  Ocular safety of hydroxychloroquine.

Authors:  H N Bernstein
Journal:  Ann Ophthalmol       Date:  1991-08

Review 8.  Ocular toxicity of hydroxychloroquine.

Authors:  J C S Yam; A K H Kwok
Journal:  Hong Kong Med J       Date:  2006-08       Impact factor: 2.227

9.  Screening for antimalarial toxicity.

Authors:  M Easterbrook
Journal:  Can J Ophthalmol       Date:  1993-04       Impact factor: 1.882

10.  Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity.

Authors:  D S Finbloom; K Silver; D A Newsome; R Gunkel
Journal:  J Rheumatol       Date:  1985-08       Impact factor: 4.666

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  7 in total

1.  Comparison of different screening methods for chloroquine/hydroxychloroquine retinopathy: multifocal electroretinography, color vision, perimetry, ophthalmoscopy, and fluorescein angiography.

Authors:  Susann Missner; Ulrich Kellner
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2012-01-04       Impact factor: 3.117

Review 2.  A Critical Review of the Effects of Hydroxychloroquine and Chloroquine on the Eye.

Authors:  Nathalie Costedoat-Chalumeau; Bertrand Dunogué; Gaëlle Leroux; Nathalie Morel; Moez Jallouli; Véronique Le Guern; Jean-Charles Piette; Antoine P Brézin; Ronald B Melles; Michael F Marmor
Journal:  Clin Rev Allergy Immunol       Date:  2015-12       Impact factor: 8.667

3.  Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the "flying saucer" sign).

Authors:  Eric Chen; David M Brown; Matthew S Benz; Richard H Fish; Tien P Wong; Rosa Y Kim; James C Major
Journal:  Clin Ophthalmol       Date:  2010-10-21

4.  Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies.

Authors:  A Molina-Martín; D P Piñero; R J Pérez-Cambrodí
Journal:  J Ophthalmol       Date:  2015-03-12       Impact factor: 1.909

5.  Detection of Hydroxychloroquine Retinal Toxicity by Automated Perimetry in 60 Rheumatoid Arthritis Patients with Normal Fundoscopic Findings.

Authors:  Qader Motarjemizadeh; Naser Samadi Aidenloo; Mohammad Abbaszadeh
Journal:  Glob J Health Sci       Date:  2015-06-25

Review 6.  Hydroxychloroquine retinopathy: A review of imaging.

Authors:  Hemang K Pandya; Mark Robinson; Nawajes Mandal; Vinay A Shah
Journal:  Indian J Ophthalmol       Date:  2015-07       Impact factor: 1.848

7.  Quantitative Fundus Autofluorescence in HCQ Retinopathy.

Authors:  Vivienne C Greenstein; Jose Ronaldo Lima de Carvalho; Rait Parmann; Luz Amaro-Quireza; Winston Lee; Donald C Hood; Stephen H Tsang; Janet R Sparrow
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-09-01       Impact factor: 4.799

  7 in total

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