OBJECTIVE: C-reactive protein (CRP) is a marker of cardiovascular disease. The objective was to determine if abdominal aortic aneurysm (AAA) and CRP serum concentration and its CRP gene are associated. METHODS AND RESULTS: AAA patients and AAA negative controls were recruited. CRP concentration was measured and the single nucleotide polymorphism (SNP), rs3091244, assessed. AAA cases were divided into those measuring 30-55 mm and >55 mm in diameter, to assess correlation of CRP with AAA size. A total of 248 (227 male) cases and 400 (388 male) controls were included. CRP concentration was higher in cases (385.0 microl/dL [310.4-442.8] vs 180.3 microl/dL [168.1-196.9]; P < .0001). It was higher in large aneurysms (685.7 microl/dL [511.8-1083.0] vs 291.0 microl/dL [223.6-349.6]; P < .0001), with significant correlation observed to size (r = 0.37, P < .0001). CC was the most common SNP genotype with no difference in distribution (P = .43) between cases and controls. No difference existed in CRP for each genotype in the overall cohort (P = .17), cases (P = .18) and controls (P = .19). CONCLUSION: The results demonstrate that CRP production may be related to the presence of AAA, especially in advanced disease. The serum concentration of CRP does not appear to be influenced by the functional SNP of the CRP gene, which also appears to have no association with AAA formation.
OBJECTIVE:C-reactive protein (CRP) is a marker of cardiovascular disease. The objective was to determine if abdominal aortic aneurysm (AAA) and CRP serum concentration and its CRP gene are associated. METHODS AND RESULTS: AAA patients and AAA negative controls were recruited. CRP concentration was measured and the single nucleotide polymorphism (SNP), rs3091244, assessed. AAA cases were divided into those measuring 30-55 mm and >55 mm in diameter, to assess correlation of CRP with AAA size. A total of 248 (227 male) cases and 400 (388 male) controls were included. CRP concentration was higher in cases (385.0 microl/dL [310.4-442.8] vs 180.3 microl/dL [168.1-196.9]; P < .0001). It was higher in large aneurysms (685.7 microl/dL [511.8-1083.0] vs 291.0 microl/dL [223.6-349.6]; P < .0001), with significant correlation observed to size (r = 0.37, P < .0001). CC was the most common SNP genotype with no difference in distribution (P = .43) between cases and controls. No difference existed in CRP for each genotype in the overall cohort (P = .17), cases (P = .18) and controls (P = .19). CONCLUSION: The results demonstrate that CRP production may be related to the presence of AAA, especially in advanced disease. The serum concentration of CRP does not appear to be influenced by the functional SNP of the CRP gene, which also appears to have no association with AAA formation.
Authors: Irene Hinterseher; Robert Erdman; Larry A Donoso; Tamara R Vrabec; Charles M Schworer; John H Lillvis; Amy M Boddy; Kimberly Derr; Alicia Golden; William D Bowen; Zoran Gatalica; Nikos Tapinos; James R Elmore; David P Franklin; John L Gray; Robert P Garvin; Glenn S Gerhard; David J Carey; Gerard Tromp; Helena Kuivaniemi Journal: Arterioscler Thromb Vasc Biol Date: 2011-04-14 Impact factor: 8.311
Authors: Ellie Paige; Marc Clément; Fabien Lareyre; Michael Sweeting; Juliette Raffort; Céline Grenier; Alison Finigan; James Harrison; James E Peters; Benjamin B Sun; Adam S Butterworth; Seamus C Harrison; Matthew J Bown; Jes S Lindholt; Stephen A Badger; Iftikhar J Kullo; Janet Powell; Paul E Norman; D Julian A Scott; Marc A Bailey; Stefan Rose-John; John Danesh; Daniel F Freitag; Dirk S Paul; Ziad Mallat Journal: Circ Genom Precis Med Date: 2019-02
Authors: Laura Lopez-Sanz; Susana Bernal; Luna Jimenez-Castilla; Ignacio Prieto; Sara La Manna; Sergio Gomez-Lopez; Luis Miguel Blanco-Colio; Jesus Egido; Jose Luis Martin-Ventura; Carmen Gomez-Guerrero Journal: Clin Transl Med Date: 2021-07