OBJECTIVE: To investigate the prescription pattern of antiemetic medications in 0- to 9-year-old children with infectious gastroenteritis in several industrialized countries during 2005. STUDY DESIGN: We retrospectively retrieved data from 4 national and international databases (IMS MIDAS, IMS disease analyzer, WIdO databases). RESULTS: Between 2% and 23% of children with gastroenteritis (International Classification of Diseases code A08.X or A09) received prescriptions for antiemetic medications (United States, 23%; 95% CI, 15-31; Germany, 17%; 95% CI, 15-20; France, 17%; 95% CI, 14-19; Spain, 15%; 95% CI, 10-19; Italy, 11%; 95% CI, 7-16; Canada, 3%; 95% CI, 0-16; United Kingdom, 2%; 95% CI, 1-2). The antihistamines dimenhydrinate and diphenhydramine were most frequently used in Germany and Canada, whereas promethazine was prescribed preferentially in the United States. In France, Spain, and Italy, the dopamine receptor antagonist domperidone was preferred as antiemetic treatment. Ondansetron was used in a minor proportion of antiemetic prescriptions (Germany, Canada, Spain, and Italy, 0%; United States, 3%; United Kingdom, 6%). CONCLUSION: Antiemetic drugs are frequently used in children with gastroenteritis. In different industrialized countries, prescription of antiemetic medication varies considerably. Ondansetron, the only drug with evidence-based antiemetic efficacy, plays a minor role among antiemetic prescriptions.
OBJECTIVE: To investigate the prescription pattern of antiemetic medications in 0- to 9-year-old children with infectious gastroenteritis in several industrialized countries during 2005. STUDY DESIGN: We retrospectively retrieved data from 4 national and international databases (IMS MIDAS, IMS disease analyzer, WIdO databases). RESULTS: Between 2% and 23% of children with gastroenteritis (International Classification of Diseases code A08.X or A09) received prescriptions for antiemetic medications (United States, 23%; 95% CI, 15-31; Germany, 17%; 95% CI, 15-20; France, 17%; 95% CI, 14-19; Spain, 15%; 95% CI, 10-19; Italy, 11%; 95% CI, 7-16; Canada, 3%; 95% CI, 0-16; United Kingdom, 2%; 95% CI, 1-2). The antihistamines dimenhydrinate and diphenhydramine were most frequently used in Germany and Canada, whereas promethazine was prescribed preferentially in the United States. In France, Spain, and Italy, the dopamine receptor antagonist domperidone was preferred as antiemetic treatment. Ondansetron was used in a minor proportion of antiemetic prescriptions (Germany, Canada, Spain, and Italy, 0%; United States, 3%; United Kingdom, 6%). CONCLUSION: Antiemetic drugs are frequently used in children with gastroenteritis. In different industrialized countries, prescription of antiemetic medication varies considerably. Ondansetron, the only drug with evidence-based antiemetic efficacy, plays a minor role among antiemetic prescriptions.
Authors: Federico Marchetti; Alessandra Maestro; Francesca Rovere; Davide Zanon; Alberto Arrighini; Paolo Bertolani; Paolo Biban; Liviana Da Dalt; Pasquale Di Pietro; Salvatore Renna; Andrea Guala; Francesco Mannelli; Anna Pazzaglia; Gianni Messi; Francesco Perri; Antonino Reale; Antonio Francesco Urbino; Enrico Valletta; Antonio Vitale; Tiziana Zangardi; Maria Teresa Tondelli; Antonio Clavenna; Maurizio Bonati; Luca Ronfani Journal: BMC Pediatr Date: 2011-02-10 Impact factor: 2.125
Authors: Federico Marchetti; Maurizio Bonati; Alessandra Maestro; Davide Zanon; Francesca Rovere; Alberto Arrighini; Egidio Barbi; Paolo Bertolani; Paolo Biban; Liviana Da Dalt; Andrea Guala; Elisa Mazzoni; Anna Pazzaglia; Paolo Francesco Perri; Antonino Reale; Salvatore Renna; Antonio Francesco Urbino; Enrico Valletta; Antonio Vitale; Tiziana Zangardi; Antonio Clavenna; Luca Ronfani Journal: PLoS One Date: 2016-11-23 Impact factor: 3.240