Literature DB >> 18827602

Telomeres and telomerase in lung cancer.

Ignacio Fernandez-Garcia1, Carlos Ortiz-de-Solorzano, Luis M Montuenga.   

Abstract

Protected telomeres ensure normal chromosomal segregation during mitosis but at the same time can endow genetically abnormal cancer cells with immortality. Telomerase has a pivotal role in telomere protection, both in normal and cancer cells. Understanding the functional interplay between telomere shortening and telomerase expression in cancer cells is of critical importance to elucidating the precise mechanisms by which these cells are able to bypass telomere crisis and become immortal.

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Year:  2008        PMID： 18827602     DOI： 10.1097/JTO.0b013e3181886713

Source DB:  PubMed          Journal:  J Thorac Oncol        ISSN： 1556-0864            Impact factor:   15.609


  17 in total

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Journal:  Lung Cancer       Date:  2013-02-19       Impact factor: 5.705

3.  TERT rs2736100 polymorphism contributes to lung cancer risk: a meta-analysis including 49,869 cases and 73,464 controls.

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4.  Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer: results from Cancer and Leukemia Group B 159902.

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Journal:  Med Oncol       Date:  2014-07-19       Impact factor: 3.064

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10.  Lung cancer and interstitial lung diseases: a systematic review.

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