Literature DB >> 18826321

Tandem palladium-catalyzed N,C-coupling/carbonylation sequence for the synthesis of 2-carboxyindoles.

Tiago O Vieira1, Laura A Meaney, Yong-Ling Shi, Howard Alper.   

Abstract

Tandem palladium-catalyzed N,C-coupling/carbonylation, under 10 atm of carbon monoxide and at 110 degrees C, is a novel and efficient method for the preparation of 2-carboxyindoles. The catalyst system tolerates a variety of functional groups, and the noted indoles were obtained in good isolated yields.

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Year:  2008        PMID: 18826321     DOI: 10.1021/ol801985q

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1).

Authors:  Leepakshi Khurana; Hamed I Ali; Teresa Olszewska; Kwang H Ahn; Aparna Damaraju; Debra A Kendall; Dai Lu
Journal:  J Med Chem       Date:  2014-03-27       Impact factor: 7.446

  1 in total

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