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Literature DB >> 18824609

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.

Elena B M Breidenstein¹, Bhavjinder K Khaira, Irith Wiegand, Joerg Overhage, Robert E W Hancock.

Abstract

Pseudomonas aeruginosa offers substantial therapeutic challenges due to its high intrinsic resistance to many antibiotics and its propensity to develop mutational and/or adaptive resistance. The PA14 comprehensive mutant library was screened for mutants exhibiting either two- to eightfold increased susceptibilities (revealing genes involved in intrinsic resistance) or decreased susceptibilities (mutational resistance) to the fluoroquinolone ciprofloxacin. Thirty-five and 79 mutants with increased and decreased susceptibilities, respectively, were identified, as confirmed by broth dilution.

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Year: 2008 PMID： 18824609 PMCID： PMC2592849 DOI： 10.1128/AAC.00222-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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Review 2. DNA gyrase, topoisomerase IV, and the 4-quinolones.

Authors: K Drlica; X Zhao
Journal: Microbiol Mol Biol Rev Date: 1997-09 Impact factor: 11.056

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Authors: Ryan T Cirz; Bryan M O'Neill; Jennifer A Hammond; Steven R Head; Floyd E Romesberg
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5. Development of resistance and cross-resistance in Pseudomonas aeruginosa exposed to subinhibitory antibiotic concentrations.

Authors: Y L Wu; E M Scott; A L Po; V N Tariq
Journal: APMIS Date: 1999-06 Impact factor: 3.205

6. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin.

Authors: B W Ritchings; E C Almira; S Lory; R Ramphal
Journal: Infect Immun Date: 1995-12 Impact factor: 3.441

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Authors: Ronald L Gibson; Jane L Burns; Bonnie W Ramsey
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9. A common mechanism of cellular death induced by bactericidal antibiotics.

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Review 6. The genetic causes of convergent evolution.

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