| Literature DB >> 18824353 |
Meng Li1, Zhi Chen, Xiuping Lin, Xuan Zhang, Yuan Song, Ying Wen, Jilun Li.
Abstract
Two new recombinants of avermectin polyketide synthases were constructed by domain and module swapping in Streptomyces avermitilis 73-12. However, only the strain, S. avermitilis OI-31, formed by domain substitution could produce ivermectin. Analysis of the ivermectin synthesized gene cluster showed that decreased amount of aveC transcripts was one of the factors causing low yield of ivermectin. Overexpression of aveC could improve ivermectin yield.Entities:
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Year: 2008 PMID： 18824353 DOI： 10.1016/j.bmcl.2008.09.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823