Literature DB >> 1882420

Who's on first? The U1 snRNP-5' splice site interaction and splicing.

M Rosbash1, B Séraphin.   

Abstract

U1 small nuclear ribonucleoprotein (snRNP) is important for pre-mRNA splicing both in yeast (Saccharomyces cerevisiae) and mammalian systems. The RNA component of U1 snRNP, U1 snRNA, interacts by base pairing with pre-mRNA 5' splice sites. This article examines recent evidence suggesting that U1 snRNP is important for an early step in spliceosome assembly rather than a late step that contributes to the specificity of 5' splice-site cleavage.

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Year:  1991        PMID： 1882420     DOI： 10.1016/0968-0004(91)90073-5

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  66 in total

1.  Reduction of target gene expression by a modified U1 snRNA.

Authors:  S A Beckley; P Liu; M L Stover; S I Gunderson; A C Lichtler; D W Rowe
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

2.  Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex.

Authors:  D Zhang; M Rosbash
Journal:  Genes Dev       Date:  1999-03-01       Impact factor: 11.361

3.  Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection.

Authors:  O Puig; A Gottschalk; P Fabrizio; B Séraphin
Journal:  Genes Dev       Date:  1999-03-01       Impact factor: 11.361

4.  An exon that prevents transport of a mature mRNA.

Authors:  M A MacMorris; D A Zorio; T Blumenthal
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

5.  Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.

Authors:  C A Collins; C Guthrie
Journal:  RNA       Date:  2001-12       Impact factor: 4.942

6.  Ordered partitioning reveals extended splice-site consensus information.

Authors:  Michael Weir; Michael Rice
Journal:  Genome Res       Date:  2004-01       Impact factor: 9.043

7.  Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing.

Authors:  Noam Shomron; Hadar Malca; Ida Vig; Gil Ast
Journal:  Nucleic Acids Res       Date:  2002-10-01       Impact factor: 16.971

8.  The 5' splice site consensus RNA oligonucleotide induces assembly of U2/U4/U5/U6 small nuclear ribonucleoprotein complexes.

Authors:  K B Hall; M M Konarska
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

9.  Splicing signals in Drosophila: intron size, information content, and consensus sequences.

Authors:  S M Mount; C Burks; G Hertz; G D Stormo; O White; C Fields
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

10.  Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions.

Authors:  P A Furth; W T Choe; J H Rex; J C Byrne; C C Baker
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272
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