| Literature DB >> 18823779 |
Michael P Winters1, Darius J Robinson, Hnin Hnin Khine, Steven S Pullen, Joseph R Woska, Ernest L Raymond, Rosemarie Sellati, Charles L Cywin, Roger J Snow, Mohammed A Kashem, John P Wolak, Josephine King, Paul V Kaplita, Lisa H Liu, Thomas M Farrell, Renee DesJarlais, Gregory P Roth, Hidenori Takahashi, Kevin J Moriarty.
Abstract
A series of novel 5-aminomethyl-1H-benzimidazole based inhibitors of Itk were prepared. Structure-activity relationships, selectivity and cell activity are reported for this series. Compound 2, a potent and selective antagonist of Itk, inhibited anti-CD3 antibody induced IL-2 production in vivo in mice.Entities:
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Year: 2008 PMID： 18823779 DOI： 10.1016/j.bmcl.2008.09.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823