OBJECTIVE: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. METHOD: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. RESULTS: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. CONCLUSION: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life.
OBJECTIVE: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. METHOD: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. RESULTS: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. CONCLUSION: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life.
Authors: Jim van Os; Philippe Delespaul; Johanna Wigman; Inez Myin-Germeys; Marieke Wichers Journal: World Psychiatry Date: 2013-06 Impact factor: 49.548
Authors: Jordan E DeVylder; Ai Koyanagi; Jay Unick; Hans Oh; Boyoung Nam; Andrew Stickley Journal: Schizophr Bull Date: 2016-04-24 Impact factor: 9.306
Authors: William V Lechner; Jennifer Dahne; Kevin W Chen; Alison Pickover; Jessica M Richards; Stacey B Daughters; C W Lejuez Journal: Drug Alcohol Depend Date: 2013-01-03 Impact factor: 4.492
Authors: Evelyn J Bromet; Matthew K Nock; Sukanta Saha; Carmen C W Lim; Sergio Aguilar-Gaxiola; Ali Al-Hamzawi; Jordi Alonso; Guilherme Borges; Ronny Bruffaerts; Louisa Degenhardt; Giovanni de Girolamo; Peter de Jonge; Silvia Florescu; Oye Gureje; Josep M Haro; Yanling He; Chiyi Hu; Elie G Karam; Viviane Kovess-Masfety; Sing Lee; Jean-Pierre Lepine; Zeina Mneimneh; Fernando Navarro-Mateu; Akin Ojagbemi; José Posada-Villa; Nancy A Sampson; Kate M Scott; Juan C Stagnaro; Maria C Viana; Miguel Xavier; Ronald C Kessler; John J McGrath Journal: JAMA Psychiatry Date: 2017-11-01 Impact factor: 21.596