Literature DB >> 18821875

Overdose training and take-home naloxone for opiate users: prospective cohort study of impact on knowledge and attitudes and subsequent management of overdoses.

John Strang1, Victoria Manning, Soraya Mayet, David Best, Emily Titherington, Laura Santana, Elizabeth Offor, Claudia Semmler.   

Abstract

AIM: To examine the impact of training in overdose management and naloxone provision on the knowledge and confidence of current opiate users; and to record subsequent management of overdoses that occur during a 3-month follow-up period.
DESIGN: Repeated-measures design to examine changes in knowledge and confidence immediately after overdose management training; retention of knowledge and confidence at 3 months; and prospective cohort study design to document actual interventions applied at post-training overdose situations.
METHOD: A total of 239 opiate users in treatment completed a pre-training questionnaire on overdose management and naloxone administration and were re-assessed immediately post-training, at which point they were provided with the take-home emergency supply of naloxone. Three months later they were re-interviewed.
RESULTS: Significant improvements were seen in knowledge of risks of overdose, characteristics of overdose and appropriate actions to be taken; and in confidence in the administration of naloxone. A 78% follow-up rate was achieved (186 of 239) among whom knowledge of both the risks and physical/behavioural characteristics of overdose and also of recommended management actions was well retained. Eighteen overdoses (either experienced or witnessed) had occurred during the 3 months between the training and the follow-up. Naloxone was used on 12 occasions (a trained client's own supply on 10 occasions). One death occurred in one of the six overdoses where naloxone was not used. Where naloxone was used, all 12 resulted in successful reversal.
CONCLUSIONS: With overdose management training, opiate users can be trained to execute appropriate actions to assist the successful reversal of potentially fatal overdose. Wider provision may reduce drug-related deaths further. Future studies should examine whether public policy of wider overdose management training and naloxone provision could reduce the extent of opiate overdose fatalities, particularly at times of recognized increased risk.

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Year:  2008        PMID: 18821875     DOI: 10.1111/j.1360-0443.2008.02314.x

Source DB:  PubMed          Journal:  Addiction        ISSN: 0965-2140            Impact factor:   6.526


  58 in total

1.  'I saved a life': a heroin addict's reflections on managing an overdose using 'take home naloxone'.

Authors:  Sanju George; Sylvie Boulay; Damion Begley
Journal:  BMJ Case Rep       Date:  2010-09-07

2.  Characteristics of drug users who witness many overdoses: implications for overdose prevention.

Authors:  Amy S B Bohnert; Melissa Tracy; Sandro Galea
Journal:  Drug Alcohol Depend       Date:  2011-08-12       Impact factor: 4.492

3.  High risk and little knowledge: overdose experiences and knowledge among young adult nonmedical prescription opioid users.

Authors:  David Frank; Pedro Mateu-Gelabert; Honoria Guarino; Alex Bennett; Travis Wendel; Lauren Jessell; Anastasia Teper
Journal:  Int J Drug Policy       Date:  2014-07-31

Review 4.  Naloxone dosage for opioid reversal: current evidence and clinical implications.

Authors:  Rachael Rzasa Lynn; J L Galinkin
Journal:  Ther Adv Drug Saf       Date:  2017-12-13

5.  Preventing opiate overdose deaths: examining objections to take-home naloxone.

Authors:  Alexander R Bazazi; Nickolas D Zaller; Jeannia J Fu; Josiah D Rich
Journal:  J Health Care Poor Underserved       Date:  2010-11

6.  Schwartz et al. respond.

Authors:  Robert P Schwartz; Jan Gryczynski; Kevin E O'Grady; Joshua M Sharfstein; Gregory Warren; Yngvild K Olsen; Shannon Gwin Mitchell; Jerome H Jaffe
Journal:  Am J Public Health       Date:  2013-06-13       Impact factor: 9.308

7.  A response to the opioid overdose epidemic: naloxone nasal spray.

Authors:  Daniel P Wermeling
Journal:  Drug Deliv Transl Res       Date:  2013-02-01       Impact factor: 4.617

8.  Opioid Overdose: Risk Assessment and Mitigation in Outpatient Treatment.

Authors:  Lewei Allison Lin; Avinash Hosanagar; Tae Woo Park; Amy S B Bohnert
Journal:  J Addict Med       Date:  2016 Nov/Dec       Impact factor: 3.702

9.  Overdose prevention and naloxone prescription for opioid users in San Francisco.

Authors:  Lauren Enteen; Joanna Bauer; Rachel McLean; Eliza Wheeler; Emalie Huriaux; Alex H Kral; Joshua D Bamberger
Journal:  J Urban Health       Date:  2010-12       Impact factor: 3.671

10.  Can we prevent drug related deaths by training opioid users to recognise and manage overdoses?

Authors:  Romina Lopez Gaston; David Best; Victoria Manning; Ed Day
Journal:  Harm Reduct J       Date:  2009-09-25
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