Frank LoVecchio1, Kenneth Katz, David Watts, Ian Wood. 1. Banner Good Samaritan Regional Poison Center, Maricopa Medical Center, Department of Emergency Medicine, Phoenix, AZ, USA. Frank.LoVecchio@bannerhealth.com
Abstract
INTRODUCTION: Unintentional methotrexate (MTX) acute oral overdose is rarely reported. METHODS: We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003. RESULTS: Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred. DISCUSSION: Although intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.
INTRODUCTION: Unintentional methotrexate (MTX) acute oral overdose is rarely reported. METHODS: We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003. RESULTS: Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred. DISCUSSION: Although intravenous MTXtoxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.
Authors: Marc Ghannoum; Darren M Roberts; David S Goldfarb; Jesper Heldrup; Kurt Anseeuw; Tais F Galvao; Thomas D Nolin; Robert S Hoffman; Valery Lavergne; Paul Meyers; Sophie Gosselin; Tudor Botnaru; Karine Mardini; David M Wood Journal: Clin J Am Soc Nephrol Date: 2022-03-02 Impact factor: 10.614