Literature DB >> 18821470

The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease.

Christopher L Gentile1, Michael J Pagliassotti.   

Abstract

The endoplasmic reticulum (ER) has emerged as a key to understanding the development and consequences of hepatic fat accumulation in nonalcoholic fatty liver disease (NAFLD). An essential function of this organelle is the proper assembly of proteins that are destined for intracellular organelles and the cell surface. Recent evidence suggests that chemical chaperones that enhance the functional capacity of the ER improve liver function in obesity and NAFLD. These chaperones may therefore provide a novel potential therapeutic strategy in NAFLD.

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Year:  2008        PMID： 18821470      PMCID： PMC2575374     

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


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