| Literature DB >> 18821257 |
Maud Antoine1, Pascal Marchand, Guillaume Le Baut, Michael Czech, Silke Baasner, Eckhard Gunther.
Abstract
New series of analogues of N-(pyridin-4-yl)-2-[1-(4-chlorobenzyl)-indol-3-yl]glyoxamide D-24851 were synthesized, characterized and tested for their in vitro anticancer properties. In the first series, an amino acid spacer was introduced in the glyoxamide chain of D-24851. In the second series, the glyoxamide chain was moved to positions 4 and 5 of indole skeleton. These new compounds were tested on four cancer cell lines (KB, SK-OV-3, NCI-H460 and SF-268), with promising activity for the glycine derivative.Entities:
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Year: 2008 PMID： 18821257 DOI： 10.1080/14756360802207998
Source DB: PubMed Journal: J Enzyme Inhib Med Chem ISSN： 1475-6366 Impact factor: 5.051