PURPOSE: Although a diagnosis of mesenteric necrosis can easily be made, mesenteric ischemia is sometimes overlooked, especially in the acute phase. We experimentally evaluated the time course of the lactate concentration, which may be a possibly useful variable in making a diagnosis of mesenteric ischemia, and determined how an early diagnosis can be made. METHODS: The superior mesenteric artery (SMA) was surgically ligated in an anesthetized pig. Blood tests, including a blood gas analysis, were done using samples from the superior mesenteric vein (SMV), hepatic vein, femoral vein, and artery until 6 h after SMA ligation. RESULTS: There were no variables in any samples that showed a significant change within 4 h after SMA ligation except for samples taken from the SMV. All acidosis-related variables had changed significantly within 6 h after ischemia. Among them, the lactate concentration only in the SMV was observed to have increased significantly within one hour after SMA ligation. CONCLUSIONS: Currently available peripheral blood tests, including tests using blood obtained from the hepatic vein, do not enable the detection of mesenteric ischemia within 4 h after onset. In a case in which an exploratory laparotomy is performed, the measurement of the lactate concentration in SMV is thus considered to be a useful supplementary test for making a prompt diagnosis of mesenteric ischemia in an early phase.
PURPOSE: Although a diagnosis of mesenteric necrosis can easily be made, mesenteric ischemia is sometimes overlooked, especially in the acute phase. We experimentally evaluated the time course of the lactate concentration, which may be a possibly useful variable in making a diagnosis of mesenteric ischemia, and determined how an early diagnosis can be made. METHODS: The superior mesenteric artery (SMA) was surgically ligated in an anesthetized pig. Blood tests, including a blood gas analysis, were done using samples from the superior mesenteric vein (SMV), hepatic vein, femoral vein, and artery until 6 h after SMA ligation. RESULTS: There were no variables in any samples that showed a significant change within 4 h after SMA ligation except for samples taken from the SMV. All acidosis-related variables had changed significantly within 6 h after ischemia. Among them, the lactate concentration only in the SMV was observed to have increased significantly within one hour after SMA ligation. CONCLUSIONS: Currently available peripheral blood tests, including tests using blood obtained from the hepatic vein, do not enable the detection of mesenteric ischemia within 4 h after onset. In a case in which an exploratory laparotomy is performed, the measurement of the lactate concentration in SMV is thus considered to be a useful supplementary test for making a prompt diagnosis of mesenteric ischemia in an early phase.
Authors: A Brillantino; F Iacobellis; A Renzi; R Nasti; L Saldamarco; M Grillo; L Romano; M Castriconi; A Cittadini; M De Palma; M Scaglione; N Di Martino; R Grassi; F Paladino Journal: Eur J Trauma Emerg Surg Date: 2017-06-13 Impact factor: 3.693
Authors: Jihan Harki; Aria Sana; Désirée van Noord; Paul J van Diest; Petra van der Groep; Ernst J Kuipers; Leon M G Moons; Katharina Biermann; Eric T T L Tjwa Journal: Virchows Arch Date: 2014-11-26 Impact factor: 4.064
Authors: Désirée van Noord; Peter B F Mensink; Robert J de Knegt; Martine Ouwendijk; Jan Francke; Anneke J van Vuuren; Bettina E Hansen; Ernst J Kuipers Journal: Dig Dis Sci Date: 2010-07-15 Impact factor: 3.199
Authors: Francisco Javier Guzmán-de la Garza; Juan Manuel Ibarra-Hernández; Paula Cordero-Pérez; Pablo Villegas-Quintero; Claudia Ivette Villarreal-Ovalle; Liliana Torres-González; Norma Edith Oliva-Sosa; Gabriela Alarcón-Galván; Nancy Esthela Fernández-Garza; Linda Elsa Muñoz-Espinosa; Carlos Rodrigo Cámara-Lemarroy; José Gerardo Carrillo-Arriaga Journal: Clinics (Sao Paulo) Date: 2013-07 Impact factor: 2.365