Literature DB >> 18820758

New methods for stereochemical determination of complex polyketides: configurational assignment of novel metabolites from myxobacteria.

Dirk Menche1.   

Abstract

An overview on recently developed methods for the stereochemical determination of complex polyketides is given and NMR-spectroscopic, computational, biosynthetic and synthetic methods are discussed. These methods are presented in their applications to structurally novel polyketide classes from myxobacteria.

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Year:  2008        PMID： 18820758     DOI： 10.1039/b707989n

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  6 in total

1.  Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora.

Authors:  Min Cheol Kim; Henrique Machado; Kyoung Hwa Jang; Lynnie Trzoss; Paul R Jensen; William Fenical
Journal:  J Am Chem Soc       Date:  2018-08-20       Impact factor: 15.419

2.  Synthesis of the C1-C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments.

Authors:  Jieyan Lim; Venkaiah Chintalapudi; Haraldur G Gudmundsson; Minh Tran; Alice Bernasconi; Araceli Blanco; Lijiang Song; Gregory L Challis; Edward A Anderson
Journal:  Org Lett       Date:  2021-09-08       Impact factor: 6.005

3.  An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics.

Authors:  Hui Hong; Markiyan Samborskyy; Frederick Lindner; Peter F Leadlay
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-02       Impact factor: 15.336

4.  An Effective Bifunctional Aldehyde Linchpin for Type II Anion Relay Chemistry: Development and Application to the Synthesis of a C16-C29 Fragment of Rhizopodin.

Authors:  Bruno Melillo; Ming Z Chen; Roberto Forestieri; Amos B Smith
Journal:  Org Lett       Date:  2015-12-07       Impact factor: 6.005

5.  Natural products chemistry: The emerging trends and prospective goals.

Authors:  Riaz A Khan
Journal:  Saudi Pharm J       Date:  2018-02-07       Impact factor: 4.330

6.  Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics.

Authors:  Iain R G Thistlethwaite; Freya M Bull; Chengsen Cui; Paul D Walker; Shu-Shan Gao; Luoyi Wang; Zhongshu Song; Joleen Masschelein; Rob Lavigne; Matthew P Crump; Paul R Race; Thomas J Simpson; Christine L Willis
Journal:  Chem Sci       Date:  2017-07-11       Impact factor: 9.825
  6 in total

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