Literature DB >> 18819842

NLRC4/IPAF: a CARD carrying member of the NLR family.

Fayyaz S Sutterwala1, Richard A Flavell.   

Abstract

The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4-dependent manner leading to macrophage cell death and the release of proinflammatory cytokines. This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation.

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Year:  2008        PMID： 18819842      PMCID： PMC2630383          DOI： 10.1016/j.clim.2008.08.011

Source DB:  PubMed          Journal:  Clin Immunol        ISSN： 1521-6616            Impact factor:   3.969


  43 in total

1.  Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

Authors:  J L Poyet; S M Srinivasula; M Tnani; M Razmara; T Fernandes-Alnemri; E S Alnemri
Journal:  J Biol Chem       Date:  2001-06-04       Impact factor: 5.157

2.  Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.

Authors:  H M Hoffman; J L Mueller; D H Broide; A A Wanderer; R D Kolodner
Journal:  Nat Genet       Date:  2001-11       Impact factor: 38.330

3.  Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).

Authors:  V Steimle; L A Otten; M Zufferey; B Mach
Journal:  Cell       Date:  1993-10-08       Impact factor: 41.582

4.  CARD15 mutations in Blau syndrome.

Authors:  C Miceli-Richard; S Lesage; M Rybojad; A M Prieur; S Manouvrier-Hanu; R Häfner; M Chamaillard; H Zouali; G Thomas; J P Hugot
Journal:  Nat Genet       Date:  2001-09       Impact factor: 38.330

5.  Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes.

Authors:  Jérôme Feldmann; Anne-Marie Prieur; Pierre Quartier; Patrick Berquin; Stephanie Certain; Elisabetta Cortis; Dominique Teillac-Hamel; Alain Fischer; Genevieve de Saint Basile
Journal:  Am J Hum Genet       Date:  2002-05-24       Impact factor: 11.025

6.  A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.

Authors:  Annick Mayor; Fabio Martinon; Thibaut De Smedt; Virginie Pétrilli; Jürg Tschopp
Journal:  Nat Immunol       Date:  2007-04-15       Impact factor: 25.606

7.  Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

Authors:  Sanjeev Mariathasan; Kim Newton; Denise M Monack; Domagoj Vucic; Dorothy M French; Wyne P Lee; Meron Roose-Girma; Sharon Erickson; Vishva M Dixit
Journal:  Nature       Date:  2004-06-09       Impact factor: 49.962

8.  Release of IL-1 from mononuclear phagocytes.

Authors:  K A Hogquist; E R Unanue; D D Chaplin
Journal:  J Immunol       Date:  1991-10-01       Impact factor: 5.422

9.  The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

Authors:  Fabio Martinon; Kimberly Burns; Jürg Tschopp
Journal:  Mol Cell       Date:  2002-08       Impact factor: 17.970

10.  The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation.

Authors:  M Galle; P Schotte; M Haegman; A Wullaert; H J Yang; S Jin; R Beyaert
Journal:  J Cell Mol Med       Date:  2007-12-10       Impact factor: 5.310
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  42 in total

1.  Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.

Authors:  Antonia Fettelschoss; Magdalena Kistowska; Salomé LeibundGut-Landmann; Hans-Dietmar Beer; Pål Johansen; Gabriela Senti; Emmanuel Contassot; Martin F Bachmann; Lars E French; Annette Oxenius; Thomas M Kündig
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

Review 2.  Inflammasomes and intestinal inflammation.

Authors:  N Zmora; M Levy; M Pevsner-Fishcer; E Elinav
Journal:  Mucosal Immunol       Date:  2017-04-12       Impact factor: 7.313

3.  Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.

Authors:  Shankar S Iyer; Qiong He; John R Janczy; Suzanne L Cassel; Fayyaz S Sutterwala; Eric I Elliott; Zhenyu Zhong; Alicia K Olivier; Jeffrey J Sadler; Vickie Knepper-Adrian; Renzhi Han; Liang Qiao; Stephanie C Eisenbarth; William M Nauseef
Journal:  Immunity       Date:  2013-08-15       Impact factor: 31.745

4.  Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production.

Authors:  Mikaela M Tremblay; Mahmood Y Bilal; Jon C D Houtman
Journal:  Mol Immunol       Date:  2013-10-12       Impact factor: 4.407

5.  Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer.

Authors:  Bo Hu; Eran Elinav; Samuel Huber; Till Strowig; Liming Hao; Anja Hafemann; Chengcheng Jin; Claudia Wunderlich; Thomas Wunderlich; Stephanie C Eisenbarth; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-21       Impact factor: 11.205

6.  Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.

Authors:  Emma Birnie; Tassili A F Weehuizen; Jacqueline M Lankelma; Hanna K de Jong; Gavin C K W Koh; Miriam H P van Lieshout; Joris J T H Roelofs; Andries E Budding; Alex F de Vos; Tom van der Poll; W Joost Wiersinga
Journal:  Infect Immun       Date:  2019-07-23       Impact factor: 3.441

7.  Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

Authors:  Ali A Abdul-Sater; Evonne Koo; Georg Häcker; David M Ojcius
Journal:  J Biol Chem       Date:  2009-07-31       Impact factor: 5.157

Review 8.  Inflammasomes: too big to miss.

Authors:  Andrea Stutz; Douglas T Golenbock; Eicke Latz
Journal:  J Clin Invest       Date:  2009-12-01       Impact factor: 14.808

9.  Secretion of Flagellar Proteins by the Pseudomonas aeruginosa Type III Secretion-Injectisome System.

Authors:  Dilek Ince; Fayyaz S Sutterwala; Timothy L Yahr
Journal:  J Bacteriol       Date:  2015-04-06       Impact factor: 3.490

10.  A Role for the Inflammasome in Spontaneous Labor at Term.

Authors:  Roberto Romero; Yi Xu; Olesya Plazyo; Piya Chaemsaithong; Tinnakorn Chaiworapongsa; Ronald Unkel; Nandor Gabor Than; Po Jen Chiang; Zhong Dong; Zhonghui Xu; Adi L Tarca; Vikki M Abrahams; Sonia S Hassan; Lami Yeo; Nardhy Gomez-Lopez
Journal:  Am J Reprod Immunol       Date:  2016-03-08       Impact factor: 3.886
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