| Literature DB >> 18819795 |
Chad A Lewis1, Janie Merkel, Scott J Miller.
Abstract
The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.Entities:
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Year: 2008 PMID： 18819795 PMCID： PMC2669672 DOI： 10.1016/j.bmcl.2008.09.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823