Johannes Fredrik Grimmer1, Gary Hedlund, Albert Park. 1. Division of Otolaryngology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, United States. fred.grimmer@imail.org
Abstract
OBJECTIVE: 1. Determine whether corticosteroid therapy improves hearing thresholds of patients with enlarged vestibular aqueduct (EVA) anomaly. 2. Determine sample size for a future prospective study. METHODS: Retrospective chart review hearing loss in EVA patients comparing patients treated with corticosteroids and untreated patients. RESULTS: Eighty percent (n=5) of patients treated with steroids for hearing loss demonstrated audiometric improvement, compared to 14.3% of patients (n=7) not treated. The pure tone average improved by 17.7dB in the steroid treated group. A prospective, placebo-controlled trial would need between 19 and 45 patients in each group, treatment versus no-treatment, to achieve statistical significance. CONCLUSION: Patients with EVA who develop hearing loss have a high rate of hearing improvement when treated with corticosteroid therapy. The hearing improvement appears to be better than spontaneous recovery.
OBJECTIVE: 1. Determine whether corticosteroid therapy improves hearing thresholds of patients with enlarged vestibular aqueduct (EVA) anomaly. 2. Determine sample size for a future prospective study. METHODS: Retrospective chart review hearing loss in EVA patients comparing patients treated with corticosteroids and untreated patients. RESULTS: Eighty percent (n=5) of patients treated with steroids for hearing loss demonstrated audiometric improvement, compared to 14.3% of patients (n=7) not treated. The pure tone average improved by 17.7dB in the steroid treated group. A prospective, placebo-controlled trial would need between 19 and 45 patients in each group, treatment versus no-treatment, to achieve statistical significance. CONCLUSION:Patients with EVA who develop hearing loss have a high rate of hearing improvement when treated with corticosteroid therapy. The hearing improvement appears to be better than spontaneous recovery.
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