| Literature DB >> 18817984 |
Y Yasuda1, T Shimoda, K Uno, N Tateishi, S Furuya, K Yagi, K Suzuki, S Fujita.
Abstract
The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18817984 DOI： 10.1016/j.jneuroim.2008.08.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478