INTRODUCTION: Carotid stenting (CS) has become a therapeutic alternative to endarterectomy in selected patients. Periinterventional plaque thromboembolism leading to neurological ischemic events remain the major risk of the procedure. We prospectively studied the potential role of thrombophilic conditions including anticardiolipin antibodies (ACA, IgG and IgM isotype), lupus anticoagulants, activated protein C resistance, antithrombin, and protein C and S. MATERIAL AND METHODS: The study was approved by the local ethics committee, and written informed consent was obtained from all patients. In total, 236 consecutive patients were included (158 men, 78 woman; median age 73 years). Prothrombotic markers were quantitated on the day of admission. Periprocedural neurological deficits (PND) occurring within 48 hours of the intervention were recorded and classified by an independent neurologist as transient ischemic attack, minor or major stroke. Uni- and multivariable logistic regression analysis were performed to test for the influence of thrombophilic conditions, demographic factors and lesion characteristics on PND. RESULTS: Neurologic complications occurred in 18 interventions (7.6%). In 4 (36.4%; 3 minor, 1major stroke) out of 11 patients with elevated IgG-ACA neurological events were observed as compared to 14 (6.2%; 6 TIA, 5 minor stroke, 3 major stroke) out of 225 patients with normal IgG-ACA levels. In multivariable analysis, two variables were independently associated with PND: elevated IgG-ACA (OR 6.09, 95% CI 1.49-25.88; P=0.012) and lesion length >10 mm (OR 4.36, 95% CI 1.19 to 16.01; P=0.027). CONCLUSIONS: A thrombophilic condition due to elevation of anticardiolipin antibodies increases the risk of periinterventional neurological complications during CS.
INTRODUCTION: Carotid stenting (CS) has become a therapeutic alternative to endarterectomy in selected patients. Periinterventional plaque thromboembolism leading to neurological ischemic events remain the major risk of the procedure. We prospectively studied the potential role of thrombophilic conditions including anticardiolipin antibodies (ACA, IgG and IgM isotype), lupus anticoagulants, activated protein C resistance, antithrombin, and protein C and S. MATERIAL AND METHODS: The study was approved by the local ethics committee, and written informed consent was obtained from all patients. In total, 236 consecutive patients were included (158 men, 78 woman; median age 73 years). Prothrombotic markers were quantitated on the day of admission. Periprocedural neurological deficits (PND) occurring within 48 hours of the intervention were recorded and classified by an independent neurologist as transient ischemic attack, minor or major stroke. Uni- and multivariable logistic regression analysis were performed to test for the influence of thrombophilic conditions, demographic factors and lesion characteristics on PND. RESULTS:Neurologic complications occurred in 18 interventions (7.6%). In 4 (36.4%; 3 minor, 1major stroke) out of 11 patients with elevated IgG-ACA neurological events were observed as compared to 14 (6.2%; 6 TIA, 5 minor stroke, 3 major stroke) out of 225 patients with normal IgG-ACA levels. In multivariable analysis, two variables were independently associated with PND: elevated IgG-ACA (OR 6.09, 95% CI 1.49-25.88; P=0.012) and lesion length >10 mm (OR 4.36, 95% CI 1.19 to 16.01; P=0.027). CONCLUSIONS: A thrombophilic condition due to elevation of anticardiolipin antibodies increases the risk of periinterventional neurological complications during CS.
Authors: Christian L Seifert; Markus C Kowarik; Klaus Thürmel; Achim Berthele; Sascha Prothmann; Silke Wunderlich Journal: Ann Clin Transl Neurol Date: 2015-05-25 Impact factor: 4.511