| Literature DB >> 18817833 |
Vitaly Ablamunits1, Kevan C Herold.
Abstract
Recent studies with a humanized anti-CD3 antibody in clinical trials suggested that this drug can induce regulatory CD8+ T cells. In this review, we discuss how these regulatory human CD8+ cells can be generated and the possible molecular tools they may use to inhibit immune responses. We compare our data on CD8+ regulatory cells induced by anti-CD3 stimulation with those reported in other experimental systems to identify both common and unique features of these cells.Entities:
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Year: 2008 PMID： 18817833 DOI： 10.1016/j.humimm.2008.08.290
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850