| Literature DB >> 18817403 |
Rahul S Khupse1, Paul W Erhardt.
Abstract
The first total syntheses of racemic glyceollin I and its enantiomers are described. A Wittig approach was utilized as an entry to the appropriately substituted isoflav-3-ene so that an osmium tetroxide mediated asymmetric dihydroxylation could be deployed for stereospecific introduction of the 6a-hydroxy group. While using triphenylphosphine hydrobromide, a novel method was found for gently removing MOM from protected phenolic hydroxyl groups present within sensitive systems.Entities:
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Year: 2008 PMID： 18817403 DOI： 10.1021/ol802112r
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005