| Literature DB >> 18816532 |
Yoshihito Shiono1, Fuminori Hiramatsu, Tetsuya Murayama, Takuya Koseki, Takayuki Funakoshi.
Abstract
The structures of two new cyathane-type diterpenoids isolated from a liquid culture of Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene and (12R)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhibitory activity against YMB and COLO 201 cells.Entities:
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Year: 2008 PMID： 18816532 DOI： 10.1002/cbdv.200890170
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408