Literature DB >> 1881631

Domoic acid induced seizure activity in rats.

K Dakshinamurti1, S K Sharma, M Sundaram.   

Abstract

Domoic acid, in increasing doses (10-300 pmol), was microinjected into the hippocampal CA3 region of rats. All rats consistently exhibited generalized bilateral electrical seizure discharge activity at 100 pmol of domoic acid. Seizure latency varied inversely with the dose of domoic acid in the range tested. Local hippocampal administration of gamma-aminobutyric acid (GABA) resulted in neuronal recovery from domoic acid-induced seizures. The seizure activity of domoic acid might be the result of decreased GABAergic inhibition.

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Year:  1991        PMID： 1881631     DOI： 10.1016/0304-3940(91)90792-r

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Power spectrum analysis of EEG in a translational nonhuman primate model after chronic exposure to low levels of the common marine neurotoxin, domoic acid.

Authors:  R Petroff; M Murias; K S Grant; B Crouthamel; N McKain; S Shum; J Jing; N Isoherranen; T M Burbacher
Journal:  Neurotoxicology       Date:  2020-07-24       Impact factor: 4.294

Review 2.  Domoic acid-induced neurotoxicity in the hippocampus of adult rats.

Authors:  Ananth Chandrasekaran; Gopalakrishnakone Ponnambalam; Charanjit Kaur
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

3.  Suppression of domoic acid induced seizures by 8-(OH)-DPAT.

Authors:  S K Sharma; K Dakshinamurti
Journal:  J Neural Transm Gen Sect       Date:  1993

4.  The release of glutamate and aspartate from rat brain synaptosomes in response to domoic acid (amnesic shellfish toxin) and kainic acid.

Authors:  J A Brown; M S Nijjar
Journal:  Mol Cell Biochem       Date:  1995-10-04       Impact factor: 3.396

5.  Fetal domoic acid exposure affects lateral amygdala neurons, diminishes social investigation and alters sensory-motor gating.

Authors:  D G Zuloaga; G P Lahvis; B Mills; H L Pearce; J Turner; J Raber
Journal:  Neurotoxicology       Date:  2016-01-18       Impact factor: 4.294

6.  Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses.

Authors:  Kathi A Lefebvre; Susan C Tilton; Theo K Bammler; Richard P Beyer; Sengkeo Srinouanprachan; Patricia L Stapleton; Federico M Farin; Evan P Gallagher
Journal:  Toxicol Sci       Date:  2008-10-20       Impact factor: 4.849

Review 7.  What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine.

Authors:  Garet Paul Lahvis
Journal:  EPMA J       Date:  2017-09-12       Impact factor: 6.543

8.  Domoic Acid-Induced Neurotoxicity Is Mainly Mediated by the AMPA/KA Receptor: Comparison between Immature and Mature Primary Cultures of Neurons and Glial Cells from Rat Cerebellum.

Authors:  Helena T Hogberg; Anna K Bal-Price
Journal:  J Toxicol       Date:  2011-11-02

Review 9.  Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence.

Authors:  Rebekah Petroff; Alicia Hendrix; Sara Shum; Kimberly S Grant; Kathi A Lefebvre; Thomas M Burbacher
Journal:  Pharmacol Ther       Date:  2021-04-28       Impact factor: 12.310

10.  Heart Alterations after Domoic Acid Administration in Rats.

Authors:  Andres C Vieira; José Manuel Cifuentes; Roberto Bermúdez; Sara F Ferreiro; Albina Román Castro; Luis M Botana
Journal:  Toxins (Basel)       Date:  2016-03-10       Impact factor: 4.546
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