| Literature DB >> 1881606 |
K Alhainen1, J Partanen, K Reinikainen, V Laulumaa, H Soininen, M Airaksinen, P Riekkinen.
Abstract
We report the results of our study suggesting that a single dose pharmaco-EEG may predict treatment response to tetrahydroaminoacridine (THA) in Alzheimer's disease (AD). 14 AD patients and 7 age-matched neurologically healthy controls were selected for the study. AD patients had 7 weeks' THA treatment. 6 patients were regarded as responders and 8 patients as nonresponders, respectively. AD patients as well as controls had a baseline EEG recording and next day another recording 90 minutes after a peroral single dose of 50 mg THA. The relative change from the baseline in the alpha-theta ratio was the most sensitive discriminator of responders and nonresponders (P = 0.004, ANOVA).Entities:
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Year: 1991 PMID： 1881606 DOI： 10.1016/0304-3940(91)90907-b
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046