Lesions of the medial septal nucleus produce a long-lasting inhibition of T lymphocyte proliferation.

The influence of the central cholinergic system on the immune system was studied in Wistar rats by lesioning the medial septal nucleus. This lesion inhibited T cell proliferation of splenocytes and thymocytes induced by the mitogens concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) up to 25 days and did not affect proliferation at 40 days after lesioning. In contrast, the response to the B cell mitogen lipopolysaccharide from E. coli (LPS) was not affected at any time. These findings suggest a regulatory role of the cholinergic medial septal nucleus on T lymphocyte proliferation.