Literature DB >> 18815703

Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents.

Domingo García-Cuadrado1, Sofia Barluenga, Nicolas Winssinger.   

Abstract

A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.

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Year:  2008        PMID: 18815703     DOI: 10.1039/b807869f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Toward a symphony of reactivity: cascades involving catalysis and sigmatropic rearrangements.

Authors:  Amanda C Jones; Jeremy A May; Richmond Sarpong; Brian M Stoltz
Journal:  Angew Chem Int Ed Engl       Date:  2014-03-03       Impact factor: 15.336

2.  Skeletal diversity via cationic rearrangements of substituted dihydropyrans.

Authors:  Matthew R Medeiros; Radha S Narayan; Nolan T McDougal; Scott E Schaus; John A Porco
Journal:  Org Lett       Date:  2010-07-16       Impact factor: 6.005

  2 in total

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