Literature DB >> 18815486

Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?

Scott E Gordon1, Jordan A Lake, Christopher M Westerkamp, David M Thomson.   

Abstract

The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.

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Year:  2008        PMID： 18815486      PMCID： PMC2659413          DOI： 10.1097/JES.0b013e3181877e13

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  28 in total

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Authors:  Douglas R Bolster; Stephen J Crozier; Scot R Kimball; Leonard S Jefferson
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4.  Phosphagens and glycogen content in skeletal muscle after treadmill training in young and old rats.

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5.  Influence of age and resistance exercise on human skeletal muscle proteolysis: a microdialysis approach.

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Journal:  J Physiol       Date:  2003-11-07       Impact factor: 5.182

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Review 7.  AMP-activated protein kinase: a key system mediating metabolic responses to exercise.

Authors:  D Grahame Hardie
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8.  Age-related changes in skeletal-muscle myosin heavy-chain composition: effect of mechanical loading.

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Authors:  Micah J Drummond; Hans C Dreyer; Bart Pennings; Christopher S Fry; Shaheen Dhanani; Edgar L Dillon; Melinda Sheffield-Moore; Elena Volpi; Blake B Rasmussen
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Authors:  Jascha D Parkington; Nathan K LeBrasseur; Adam P Siebert; Roger A Fielding
Journal:  J Appl Physiol (1985)       Date:  2004-03-19
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  15 in total

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Review 2.  Sarcopenia in critically ill patients.

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Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-10-06       Impact factor: 6.053

4.  Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice.

Authors:  Jean-Philippe Leduc-Gaudet; Martin Picard; Félix St-Jean Pelletier; Nicolas Sgarioto; Marie-Joëlle Auger; Joanne Vallée; Richard Robitaille; David H St-Pierre; Gilles Gouspillou
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Review 6.  Molecular and phenotypic biomarkers of aging.

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7.  MST1, a key player, in enhancing fast skeletal muscle atrophy.

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8.  Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses.

Authors:  Gilles Gouspillou; Martin Picard; Richard Godin; Yan Burelle; Russell T Hepple
Journal:  Longev Healthspan       Date:  2013-08-01

9.  Mitochondrial energetics is impaired in vivo in aged skeletal muscle.

Authors:  Gilles Gouspillou; Isabelle Bourdel-Marchasson; Richard Rouland; Guillaume Calmettes; Marc Biran; Véronique Deschodt-Arsac; Sylvain Miraux; Eric Thiaudiere; Philippe Pasdois; Dominique Detaille; Jean-Michel Franconi; Marion Babot; Véronique Trézéguet; Laurent Arsac; Philippe Diolez
Journal:  Aging Cell       Date:  2013-09-19       Impact factor: 9.304

10.  Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.

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Journal:  Diabetes       Date:  2015-09-17       Impact factor: 9.461
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