Literature DB >> 18815234

Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level.

A L Erickson1, C B Willberg, V McMahan, A Liu, S P Buchbinder, L A Grohskopf, R M Grant, D F Nixon.   

Abstract

We measured CD8(+) T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.

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Year:  2008        PMID： 18815234      PMCID： PMC2583520          DOI： 10.1128/CVI.00247-08

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  32 in total

1.  Dendritic cell amplification of HIV type 1-specific CD8+ T cell responses in exposed, seronegative heterosexual women.

Authors:  Barbara L Shacklett; Robert E Means; Marie Larsson; David T Wilkens; Thomas J Beadle; Melissa J Merritt; Nina Bhardwaj; Paul E Palumbo; Joan H Skurnick; Donald B Louria; Douglas F Nixon
Journal:  AIDS Res Hum Retroviruses       Date:  2002-07-20       Impact factor: 2.205

2.  HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.

Authors:  Mathias Lichterfeld; Xu G Yu; Michael T Waring; Stanley K Mui; Mary N Johnston; Daniel Cohen; Marylyn M Addo; John Zaunders; Galit Alter; Eunice Pae; Daryld Strick; Todd M Allen; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Journal:  Blood       Date:  2004-04-01       Impact factor: 22.113

3.  Non-cytotoxic inhibition of HIV-1 infection by unstimulated CD8+ T lymphocytes from HIV-exposed-uninfected individuals.

Authors:  Lucinda Furci; Lucia Lopalco; Patrizia Loverro; Marina Sinnone; Giuseppe Tambussi; Adriano Lazzarin; Paolo Lusso
Journal:  AIDS       Date:  2002-05-03       Impact factor: 4.177

4.  Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.

Authors:  Xu G Yu; Marylyn M Addo; Eric S Rosenberg; William R Rodriguez; Paul K Lee; Cecily A Fitzpatrick; Mary N Johnston; Daryld Strick; Philip J R Goulder; Bruce D Walker; Marcus Altfeld
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

5.  Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals.

Authors:  Anthony Kebba; Pontiano Kaleebu; Samantha Rowland; Rebecca Ingram; Jimmy Whitworth; Nesrina Imami; Frances Gotch
Journal:  J Infect Dis       Date:  2004-04-19       Impact factor: 5.226

6.  Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.

Authors:  Todd M Allen; Marcus Altfeld; Xu G Yu; Kristin M O'Sullivan; Mathias Lichterfeld; Sylvie Le Gall; Mina John; Bianca R Mothe; Paul K Lee; Elizabeth T Kalife; Daniel E Cohen; Kenneth A Freedberg; Daryld A Strick; Mary N Johnston; Alessandro Sette; Eric S Rosenberg; Simon A Mallal; Philip J R Goulder; Christian Brander; Bruce D Walker
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

7.  Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals.

Authors:  Tuofu Zhu; Lawrence Corey; Yon Hwangbo; Jean M Lee; Gerald H Learn; James I Mullins; M Juliana McElrath
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

8.  Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells.

Authors:  Florian Hladik; Anthony Desbien; Jean Lang; Lei Wang; Yan Ding; Sarah Holte; Aaron Wilson; Younong Xu; Micky Moerbe; Steve Schmechel; M Juliana McElrath
Journal:  J Immunol       Date:  2003-09-01       Impact factor: 5.422

9.  Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.

Authors:  M Altfeld; E S Rosenberg; R Shankarappa; J S Mukherjee; F M Hecht; R L Eldridge; M M Addo; S H Poon; M N Phillips; G K Robbins; P E Sax; S Boswell; J O Kahn; C Brander; P J Goulder; J A Levy; J I Mullins; B D Walker
Journal:  J Exp Med       Date:  2001-01-15       Impact factor: 14.307

10.  Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.

Authors:  S A Stranford; J Skurnick; D Louria; D Osmond; S Y Chang; J Sninsky; G Ferrari; K Weinhold; C Lindquist; J A Levy
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205
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  19 in total

1.  Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial.

Authors:  Peter J Kuebler; Megha L Mehrotra; J Jeff McConnell; Sara J Holditch; Brian I Shaw; Leandro F Tarosso; Kaitlyn S Leadabrand; Jeffrey M Milush; Vanessa A York; Rui André Saraiva Raposo; Rex G Cheng; Emily M Eriksson; Vanessa McMahan; David V Glidden; Stephen Shiboski; Robert M Grant; Douglas F Nixon; Esper G Kallás
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

Review 2.  Evidence for the innate immune response as a correlate of protection in human immunodeficiency virus (HIV)-1 highly exposed seronegative subjects (HESN).

Authors:  C Tomescu; S Abdulhaqq; L J Montaner
Journal:  Clin Exp Immunol       Date:  2011-03-17       Impact factor: 4.330

3.  Epitope mapping of HIV-specific CD8+ T cell responses by multiple immunological readouts reveals distinct specificities defined by function.

Authors:  Meika Richmond; Lyle R McKinnon; Sandra A Koesters Kiazyk; Charles Wachihi; Makobu Kimani; Joshua Kimani; Francis A Plummer; T Blake Ball
Journal:  J Virol       Date:  2010-11-17       Impact factor: 5.103

4.  CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.

Authors:  Kristin Scheible; Gang Zhang; Jane Baer; Mitra Azadniv; Kris Lambert; Gloria Pryhuber; John J Treanor; David J Topham
Journal:  Vaccine       Date:  2011-01-04       Impact factor: 3.641

5.  Repeated Vaginal SHIV Challenges in Macaques Receiving Oral or Topical Preexposure Prophylaxis Induce Virus-Specific T-Cell Responses.

Authors:  Theodros S Tsegaye; Katherine Butler; Wei Luo; Jessica Radzio; Priya Srinivasan; Sunita Sharma; Rachael D Aubert; Debra L Hanson; Charles Dobard; Jose Gerardo Garcia-Lerma; Walid Heneine; Janet M McNicholl; Ellen N Kersh
Journal:  J Acquir Immune Defic Syndr       Date:  2015-08-01       Impact factor: 3.731

6.  Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected.

Authors:  Marta Ruiz-Riol; Anuska Llano; Javier Ibarrondo; Jennifer Zamarreño; Karina Yusim; Vanessa Bach; Beatriz Mothe; Susana Perez-Alvarez; Marco A Fernandez; Gerard Requena; Michael Meulbroek; Ferran Pujol; Agathe Leon; Patricia Cobarsi; Bette T Korber; Bonaventura Clotet; Carmela Ganoza; Jorge Sanchez; Josep Coll; Christian Brander
Journal:  J Infect Dis       Date:  2014-09-23       Impact factor: 5.226

7.  Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.

Authors:  Adam J Ritchie; Suzanne L Campion; Jakub Kopycinski; Zoe Moodie; Z Maggie Wang; Kruti Pandya; Stephen Moore; Michael K P Liu; Simon Brackenridge; Kristin Kuldanek; Kenneth Legg; Myron S Cohen; Eric L Delwart; Barton F Haynes; Sarah Fidler; Andrew J McMichael; Nilu Goonetilleke
Journal:  J Virol       Date:  2011-01-26       Impact factor: 5.103

8.  Fragmentation of SIV-gag vaccine induces broader T cell responses.

Authors:  Adel Benlahrech; Andrea Meiser; Shanthi Herath; Timos Papagatsias; Takis Athanasopoulos; Fucheng Li; Steve Self; Veronique Bachy; Catherine Hervouet; Karen Logan; Linda Klavinskis; George Dickson; Steven Patterson
Journal:  PLoS One       Date:  2012-10-31       Impact factor: 3.240

Review 9.  Functional avidity: a measure to predict the efficacy of effector T cells?

Authors:  Selena Viganò; Daniel T Utzschneider; Matthieu Perreau; Giuseppe Pantaleo; Dietmar Zehn; Alexandre Harari
Journal:  Clin Dev Immunol       Date:  2012-11-20

10.  High resolution human leukocyte antigen class I allele frequencies and HIV-1 infection associations in Chinese Han and Uyghur cohorts.

Authors:  Yanhou Liu; Zhongfang Zhao; Tianyi Li; Qi Liao; Nicholas Kushner; Neal Y Touzjian; Yiming Shao; Yongtao Sun; Amie J Strong; Yichen Lu
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240
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