| Literature DB >> 18815034 |
Peng Xu1, Lu Liu, Zhi-ping Jin, Guang-qiang Wang, Jian Liu, Yun Li, Ping-sheng Lei.
Abstract
A series of novel 4''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria.Entities:
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Year: 2008 PMID： 18815034 DOI： 10.1016/j.bmcl.2008.09.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823