Literature DB >> 18814021

Mitochondria in malaria and related parasites: ancient, diverse and streamlined.

Michael W Mather1, Akhil B Vaidya.   

Abstract

Parasitic organisms have emerged from nearly every corner of the eukaryotic kingdom and hence display tremendous diversity of form and function. This diversity extends to their mitochondria and mitochondrion-derived organelles. While the principles of the chemiosmotic theory apply to all these pathogens, the differences from their hosts provide opportunities for therapeutic development. In this review we discuss examples of mitochondrial systems from a deep-branching phylum, Apicomplexa. Many important human pathogens, such as malaria parasites, belong to this phylum. Unique features of their mitochondria are validated targets for drugs that are selectively toxic to the parasites.

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Year:  2008        PMID： 18814021     DOI： 10.1007/s10863-008-9176-4

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   3.853


  94 in total

1.  Molecular characterization and ultrastructural localization of Plasmodium falciparum Hsp 60.

Authors:  A Das; C Syin; H Fujioka; H Zheng; N Goldman; M Aikawa; N Kumar
Journal:  Mol Biochem Parasitol       Date:  1997-09       Impact factor: 1.759

Review 2.  Mitochondria of protists.

Authors:  Michael W Gray; B Franz Lang; Gertraud Burger
Journal:  Annu Rev Genet       Date:  2004       Impact factor: 16.830

3.  Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor.

Authors:  Hong Xiang; Jeanelle McSurdy-Freed; Ganesh S Moorthy; Erin Hugger; Ramesh Bambal; Chao Han; Santiago Ferrer; Domingo Gargallo; Charles B Davis
Journal:  J Pharm Sci       Date:  2006-12       Impact factor: 3.534

4.  Characterization of the delta-aminolevulinate synthase gene homologue in P. falciparum.

Authors:  C M Wilson; A B Smith; R V Baylon
Journal:  Mol Biochem Parasitol       Date:  1996-01       Impact factor: 1.759

Review 5.  Biochemistry of Plasmodium (malarial parasites).

Authors:  I W Sherman
Journal:  Microbiol Rev       Date:  1979-12

6.  The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.

Authors:  Shigeharu Sato; R J M Wilson
Journal:  Curr Genet       Date:  2002-02-06       Impact factor: 3.886

7.  Evaluation and lead optimization of anti-malarial acridones.

Authors:  Rolf W Winter; Jane X Kelly; Martin J Smilkstein; Rozalia Dodean; Grover C Bagby; R Keaney Rathbun; Joshua I Levin; David Hinrichs; Michael K Riscoe
Journal:  Exp Parasitol       Date:  2006-07-07       Impact factor: 2.011

8.  Molecular characterization of mitochondria in asexual and sexual blood stages of Plasmodium falciparum.

Authors:  P Learngaramkul; S Petmitr; S R Krungkrai; P Prapunwattana; J Krungkrai
Journal:  Mol Cell Biol Res Commun       Date:  1999-07

9.  Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicomplexan parasite Cryptosporidium parvum: phylogenetic and therapeutic implications.

Authors:  Takashi Suzuki; Tetsuo Hashimoto; Yoshisada Yabu; Yasutoshi Kido; Kimitoshi Sakamoto; Coh-ichi Nihei; Mariko Hato; Shu-ichi Suzuki; Yuko Amano; Kazuo Nagai; Tomoyoshi Hosokawa; Nobuko Minagawa; Nobuo Ohta; Kiyoshi Kita
Journal:  Biochem Biophys Res Commun       Date:  2004-01-23       Impact factor: 3.575

10.  A mechanism for the synergistic antimalarial action of atovaquone and proguanil.

Authors:  I K Srivastava; A B Vaidya
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191
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  21 in total

1.  Effects and Mechanism of Action of Artemisinin on Mitochondria of Plasmodium berghei.

Authors:  Hong-Ping Hou; Guang-Ping Zhang; Li-Na Ma; Ping Su; Zhong-Xiu Zhang; Bao-Qiang Dai; Zu-Guang Ye
Journal:  Chin J Integr Med       Date:  2019-06-21       Impact factor: 1.978

Review 2.  An overview of structure, function, and regulation of pyruvate kinases.

Authors:  Norbert Schormann; Katherine L Hayden; Paul Lee; Surajit Banerjee; Debasish Chattopadhyay
Journal:  Protein Sci       Date:  2019-08-12       Impact factor: 6.725

3.  Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Authors:  Michael W Mather; Joanne M Morrisey; Akhil B Vaidya
Journal:  Mol Biochem Parasitol       Date:  2010-07-30       Impact factor: 1.759

4.  In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.

Authors:  Lara Liv Bajohr; Ling Ma; Christian Platte; Oliver Liesenfeld; Lutz F Tietze; Uwe Gross; Wolfgang Bohne
Journal:  Antimicrob Agents Chemother       Date:  2009-11-02       Impact factor: 5.191

5.  Isoprenoid metabolism in apicomplexan parasites.

Authors:  Leah Imlay; Audrey R Odom
Journal:  Curr Clin Microbiol Rep       Date:  2014-12-01

6.  The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system.

Authors:  Cheng Lei; S Dean Rider; Cai Wang; Haili Zhang; Xiangshi Tan; Guan Zhu
Journal:  Protein Sci       Date:  2010-11       Impact factor: 6.725

7.  Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites.

Authors:  Ludek Koreny; Roman Sobotka; Jan Janouskovec; Patrick J Keeling; Miroslav Oborník
Journal:  Plant Cell       Date:  2011-09-30       Impact factor: 11.277

8.  Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Authors:  Hangjun Ke; Joanne M Morrisey; Suresh M Ganesan; Heather J Painter; Michael W Mather; Akhil B Vaidya
Journal:  Eukaryot Cell       Date:  2011-06-17

9.  Physiological uncoupling of mitochondrial oxidative phosphorylation. Studies in different yeast species.

Authors:  Sergio Guerrero-Castillo; Daniela Araiza-Olivera; Alfredo Cabrera-Orefice; Juan Espinasa-Jaramillo; Manuel Gutiérrez-Aguilar; Luís A Luévano-Martínez; Armando Zepeda-Bastida; Salvador Uribe-Carvajal
Journal:  J Bioenerg Biomembr       Date:  2011-06       Impact factor: 2.945

10.  Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii.

Authors:  San San Lin; Uwe Gross; Wolfgang Bohne
Journal:  Eukaryot Cell       Date:  2009-03-13
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