Literature DB >> 18813321

The TRAIL apoptotic pathway in cancer onset, progression and therapy.

Ricky W Johnstone1, Ailsa J Frew, Mark J Smyth.   

Abstract

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have the signals that are generated when these receptors are activated. TNF-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy. Herein we review what is known about the molecular control of TRAIL-mediated apoptosis, the role of TRAIL in carcinogenesis and the potential therapeutic utility of recombinant TRAIL and agonistic antibodies against TRAILR1 and TRAILR2.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18813321     DOI： 10.1038/nrc2465

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  337 in total

1.  Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.

Authors:  Ji H Kim; Subash C Gupta; Byoungduck Park; Vivek R Yadav; Bharat B Aggarwal
Journal:  Mol Nutr Food Res       Date:  2011-12-07       Impact factor: 5.914

2.  Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

Authors:  Maike A Laussmann; Egle Passante; Christian T Hellwig; Bartlomiej Tomiczek; Lorna Flanagan; Jochen H M Prehn; Heinrich J Huber; Markus Rehm
Journal:  J Biol Chem       Date:  2012-03-09       Impact factor: 5.157

3.  Targeting PDGFR-β in Cholangiocarcinoma.

Authors:  Christian D Fingas; Joachim C Mertens; Nataliya Razumilava; Steven F Bronk; Alphonse E Sirica; Gregory J Gores
Journal:  Liver Int       Date:  2011-12-02       Impact factor: 5.828

4.  Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

Authors:  Roberto Bellucci; Hong-Nam Nguyen; Allison Martin; Stefan Heinrichs; Anna C Schinzel; William C Hahn; Jerome Ritz
Journal:  J Clin Invest       Date:  2012-06-11       Impact factor: 14.808

5.  Control of FLIP(L) expression and TRAIL resistance by the extracellular signal-regulated kinase1/2 pathway in breast epithelial cells.

Authors:  R Yerbes; A López-Rivas; M J Reginato; C Palacios
Journal:  Cell Death Differ       Date:  2012-06-22       Impact factor: 15.828

6.  miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma.

Authors:  Nataliya Razumilava; Steve F Bronk; Rory L Smoot; Christian D Fingas; Nathan W Werneburg; Lewis R Roberts; Justin L Mott
Journal:  Hepatology       Date:  2011-12-19       Impact factor: 17.425

7.  Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2).

Authors:  Nathan W Werneburg; Steve F Bronk; Maria Eugenia Guicciardi; Laurel Thomas; Jimmy D Dikeakos; Gary Thomas; Gregory J Gores
Journal:  J Biol Chem       Date:  2012-05-29       Impact factor: 5.157

8.  Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer.

Authors:  Perry T Yin; Shreyas Shah; Nicholas J Pasquale; Olga B Garbuzenko; Tamara Minko; Ki-Bum Lee
Journal:  Biomaterials       Date:  2015-11-12       Impact factor: 12.479

9.  Bayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells.

Authors:  Rina Gendelman; Heming Xing; Olga K Mirzoeva; Preeti Sarde; Christina Curtis; Heidi S Feiler; Paul McDonagh; Joe W Gray; Iya Khalil; W Michael Korn
Journal:  Cancer Res       Date:  2017-01-13       Impact factor: 12.701

10.  Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.

Authors:  Weilong Yao; You-Take Oh; Jiusheng Deng; Ping Yue; Liang Deng; Henry Huang; Wei Zhou; Shi-Yong Sun
Journal:  J Biol Chem       Date:  2016-08-30       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.