BACKGROUND: Information is limited about how adipokines predict the accumulation of cardiovascular (CV) risk factors or the presence of metabolic syndrome (MS) in children. METHODS AND RESULTS: The subjects were 321 children (200 boys and 121 girls; 109 normal and 212 obese) aged 6-12 years. Obesity was defined as a body mass index of >or= the 95(th) percentile for age and sex. MS was defined by using the newly established Task Force criteria. The levels of the adipokines--adiponectin, leptin, ghrelin, high sensitive C-reactive protein (CRP) and resistin--were measured. Regression analyses revealed that high leptin levels were predictive of the accumulation of CV risk factors in normal weight, obese, and entire (normal weight and obese) group of subjects. High CRP in the normal weight group and low adiponectin in the obese and the entire groups were also independently predictive of the accumulation of risk factors. A high leptin level was solely predictive of the presence of MS in obese and entire groups. CONCLUSIONS: Leptin was the most sensitive marker for predicting the accumulation of CV risk factors and the presence of MS in elementary school children. Primary prevention is important because both leptin and adiponectin levels abruptly worsened when children obtained any 1 risk factor.
BACKGROUND: Information is limited about how adipokines predict the accumulation of cardiovascular (CV) risk factors or the presence of metabolic syndrome (MS) in children. METHODS AND RESULTS: The subjects were 321 children (200 boys and 121 girls; 109 normal and 212 obese) aged 6-12 years. Obesity was defined as a body mass index of >or= the 95(th) percentile for age and sex. MS was defined by using the newly established Task Force criteria. The levels of the adipokines--adiponectin, leptin, ghrelin, high sensitive C-reactive protein (CRP) and resistin--were measured. Regression analyses revealed that high leptin levels were predictive of the accumulation of CV risk factors in normal weight, obese, and entire (normal weight and obese) group of subjects. High CRP in the normal weight group and low adiponectin in the obese and the entire groups were also independently predictive of the accumulation of risk factors. A high leptin level was solely predictive of the presence of MS in obese and entire groups. CONCLUSIONS:Leptin was the most sensitive marker for predicting the accumulation of CV risk factors and the presence of MS in elementary school children. Primary prevention is important because both leptin and adiponectin levels abruptly worsened when children obtained any 1 risk factor.
Authors: Kyung M Choi; Mary Yannakoulia; Min S Park; Geum J Cho; Jung H Kim; Seung H Lee; Taik G Hwang; Sei J Yang; Tai N Kim; Hye J Yoo; Sai H Baik; Seon M Kim; Christos S Mantzoros Journal: Am J Clin Nutr Date: 2010-11-24 Impact factor: 7.045
Authors: Carla Pedrosa; Bruno M P M Oliveira; Isabel Albuquerque; Carlos Simões-Pereira; Maria Daniel Vaz-de-Almeida; Flora Correia Journal: Eur J Pediatr Date: 2010-10-19 Impact factor: 3.183
Authors: Krithika Srikanthan; Andrew Feyh; Haresh Visweshwar; Joseph I Shapiro; Komal Sodhi Journal: Int J Med Sci Date: 2016-01-01 Impact factor: 3.738