| Literature DB >> 18812259 |
Lei Zhang1, Bruce N Rogers, Allen J Duplantier, Stanley F McHardy, Ivan Efremov, Helen Berke, Weimin Qian, Andy Q Zhang, Noha Maklad, John Candler, Angela C Doran, John T Lazzaro, Alan H Ganong.
Abstract
The synthesis and structure-activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identification of potent, metabolically stable and orally available mGluR2 positive allosteric modulators (PAMs).Entities:
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Year: 2008 PMID： 18812259 DOI： 10.1016/j.bmcl.2008.09.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823