OBJECTIVES: To investigate whether anemia predicts worsening white matter hyperintensities (WMHs) in older community-dwellers. DESIGN: Prospective cohort study. SETTING: Older community-dwellers. PARTICIPANTS: One thousand eight hundred forty-six Cardiovascular Health Study (CHS) participants (mean age 73.7 +/- 4.4, 41% male, 15.6% African American). MEASUREMENTS: Participants had hemoglobin measured and brain magnetic resonance imaging (MRI) in 1992/93 and a second brain MRI in 1997/98. Anemia was defined according to World Health Organization criteria (hemoglobin <12 g/dL in women and <13 g/dL in men). Worsening WMHs were determined according to standardized side-by-side readings. RESULTS: After 5 years, WMHs worsened in 517 participants (28%). Progression was not associated with anemia in the whole sample, in sex or race strata, or in other prespecified subgroups (participants with renal dysfunction or diabetes mellitus), except in participants with high blood pressure (>or=140/90 mmHg). Of the 678 participants with high blood pressure, those with anemia (10.5%) had a 1.79 times greater risk of WMHs worsening (95% confidence interval=1.06-2.98; P for interaction between anemia and high blood pressure=.01) independent of demographics, baseline WMHs, cardiovascular risk factors and comorbidities, medications, renal function, inflammation, and incident stroke (logistic regression models). There was no greater risk in participants with anemia with normal blood pressure. CONCLUSION: Anemia may contribute to worsening of WMHs in older adults with high blood pressure.
OBJECTIVES: To investigate whether anemia predicts worsening white matter hyperintensities (WMHs) in older community-dwellers. DESIGN: Prospective cohort study. SETTING: Older community-dwellers. PARTICIPANTS: One thousand eight hundred forty-six Cardiovascular Health Study (CHS) participants (mean age 73.7 +/- 4.4, 41% male, 15.6% African American). MEASUREMENTS: Participants had hemoglobin measured and brain magnetic resonance imaging (MRI) in 1992/93 and a second brain MRI in 1997/98. Anemia was defined according to World Health Organization criteria (hemoglobin <12 g/dL in women and <13 g/dL in men). Worsening WMHs were determined according to standardized side-by-side readings. RESULTS: After 5 years, WMHs worsened in 517 participants (28%). Progression was not associated with anemia in the whole sample, in sex or race strata, or in other prespecified subgroups (participants with renal dysfunction or diabetes mellitus), except in participants with high blood pressure (>or=140/90 mmHg). Of the 678 participants with high blood pressure, those with anemia (10.5%) had a 1.79 times greater risk of WMHs worsening (95% confidence interval=1.06-2.98; P for interaction between anemia and high blood pressure=.01) independent of demographics, baseline WMHs, cardiovascular risk factors and comorbidities, medications, renal function, inflammation, and incident stroke (logistic regression models). There was no greater risk in participants with anemia with normal blood pressure. CONCLUSION:Anemia may contribute to worsening of WMHs in older adults with high blood pressure.
Authors: F-E de Leeuw; J C de Groot; M Oudkerk; J C M Witteman; A Hofman; J van Gijn; M M B Breteler Journal: Brain Date: 2002-04 Impact factor: 13.501
Authors: Hannelore Ehrenreich; Martin Hasselblatt; Christoph Dembowski; Lukas Cepek; Piotr Lewczuk; Michael Stiefel; Hans-Heino Rustenbeck; Norbert Breiter; Sonja Jacob; Friederike Knerlich; Matthias Bohn; Wolfgang Poser; Eckart Rüther; Michael Kochen; Olaf Gefeller; Christoph Gleiter; Thomas C Wessel; Marc De Ryck; Loretta Itri; Hilmar Prange; Anthony Cerami; Michael Brines; Anna-Leena Sirén Journal: Mol Med Date: 2002-08 Impact factor: 6.354
Authors: Brenda W J H Penninx; Marco Pahor; Matteo Cesari; Anna Maria Corsi; Richard C Woodman; Stephania Bandinelli; Jack M Guralnik; Luigi Ferrucci Journal: J Am Geriatr Soc Date: 2004-05 Impact factor: 5.562
Authors: Jerome L Abramson; Claudine T Jurkovitz; Viola Vaccarino; William S Weintraub; William McClellan Journal: Kidney Int Date: 2003-08 Impact factor: 10.612
Authors: W T Longstreth; Corinne Dulberg; Teri A Manolio; Michael R Lewis; Norman J Beauchamp; Daniel O'Leary; Jeff Carr; Curt D Furberg Journal: Stroke Date: 2002-10 Impact factor: 7.914
Authors: Brenda W J H Penninx; Jack M Guralnik; Graziano Onder; Luigi Ferrucci; Robert B Wallace; Marco Pahor Journal: Am J Med Date: 2003-08-01 Impact factor: 4.965
Authors: Jack M Guralnik; Richard S Eisenstaedt; Luigi Ferrucci; Harvey G Klein; Richard C Woodman Journal: Blood Date: 2004-07-06 Impact factor: 22.113
Authors: Christa A Hammond; Natalie J Blades; Sarwat I Chaudhry; John A Dodson; W T Longstreth; Susan R Heckbert; Bruce M Psaty; Alice M Arnold; Sascha Dublin; Colleen M Sitlani; Julius M Gardin; Stephen M Thielke; Michael G Nanna; Rebecca F Gottesman; Anne B Newman; Evan L Thacker Journal: Circ Heart Fail Date: 2018-03 Impact factor: 8.790
Authors: Soyoung Choi; Sharon H O'Neil; Anand A Joshi; Jian Li; Adam M Bush; Thomas D Coates; Richard M Leahy; John C Wood Journal: Am J Hematol Date: 2019-07-23 Impact factor: 10.047
Authors: Neil A Zakai; Benjamin French; Alice M Arnold; Anne B Newman; Linda F Fried; John Robbins; Paulo Chaves; Mary Cushman Journal: Am J Hematol Date: 2012-10-09 Impact factor: 10.047
Authors: Chau Vu; Adam Bush; Soyoung Choi; Matthew Borzage; Xin Miao; Aart J Nederveen; Thomas D Coates; John C Wood Journal: Am J Hematol Date: 2021-05-12 Impact factor: 13.265