Elizabeth Wohlfert1, Yasmine Belkaid. 1. Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4/126, Bethesda, MD 20892, USA.
Abstract
BACKGROUND: Various populations of regulatory cells, including Foxp3+ T(Reg), have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. OBJECTIVE: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.
BACKGROUND: Various populations of regulatory cells, including Foxp3+ T(Reg), have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. OBJECTIVE: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.
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