OBJECTIVE: We have sought to relate C-reactive protein (CRP), a peripheral marker of inflammation frequently elevated in stroke patients, with aetiology and prognosis of acute cerebral infarction. PATIENTS AND METHODS: Patients were included after a first-ever CT/MR documented cerebral infarction. CRP was measured from blood samples taken within the 6th hour of the onset. Titres of C-reactive protein were stratified in quartiles. Aetiology of stroke was from TOAST criteria. Prognosis was mortality within 14 days of stroke. RESULTS: The study included 648 stroke patients. They were 335 women and 313 men, with a mean age of 70.3 years (median 72). CRP quartiles were mostly increased in cardioembolic strokes, After logistic regression analysis CRP remained an independent factor of 14-day mortality. CONCLUSIONS: Our study suggests that in the acute phase of the cerebral infarction CRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
OBJECTIVE: We have sought to relate C-reactive protein (CRP), a peripheral marker of inflammation frequently elevated in strokepatients, with aetiology and prognosis of acute cerebral infarction. PATIENTS AND METHODS: Patients were included after a first-ever CT/MR documented cerebral infarction. CRP was measured from blood samples taken within the 6th hour of the onset. Titres of C-reactive protein were stratified in quartiles. Aetiology of stroke was from TOAST criteria. Prognosis was mortality within 14 days of stroke. RESULTS: The study included 648 strokepatients. They were 335 women and 313 men, with a mean age of 70.3 years (median 72). CRP quartiles were mostly increased in cardioembolic strokes, After logistic regression analysis CRP remained an independent factor of 14-day mortality. CONCLUSIONS: Our study suggests that in the acute phase of the cerebral infarctionCRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
Authors: Irene M Van Der Meer; Moniek P M De Maat; A Elisabeth Hak; Amanda J Kiliaan; Antonio Iglesias Del Sol; Deirdre A M Van Der Kuip; Rogier L G Nijhuis; Albert Hofman; Jacqueline C M Witteman Journal: Stroke Date: 2002-12 Impact factor: 7.914
Authors: H Hashimoto; K Kitagawa; H Hougaku; Y Shimizu; M Sakaguchi; Y Nagai; S Iyama; H Yamanishi; M Matsumoto; M Hori Journal: Circulation Date: 2001-07-03 Impact factor: 29.690
Authors: Claes Ladenvall; Katarina Jood; Christian Blomstrand; Staffan Nilsson; Christina Jern; Per Ladenvall Journal: Stroke Date: 2006-06-29 Impact factor: 7.914
Authors: Hedley C A Emsley; Craig J Smith; Carole M Gavin; Rachel F Georgiou; Andy Vail; Elisa M Barberan; John M Hallenbeck; Gregory J del Zoppo; Nancy J Rothwell; Pippa J Tyrrell; Stephen J Hopkins Journal: J Neuroimmunol Date: 2003-06 Impact factor: 3.478
Authors: Manuela Mengozzi; Frances A Kirkham; Esme E R Girdwood; Eva Bunting; Erin Drazich; Jean Timeyin; Pietro Ghezzi; Chakravarthi Rajkumar Journal: Front Immunol Date: 2020-07-07 Impact factor: 7.561