Literature DB >> 18809943

Piperacillin-tazobactam penetration into human pancreatic juice.

Elisa Bertazzoni Minelli1, Anna Benini, Luigina Franco, Claudio Bassi, Paolo Pederzoli.   

Abstract

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimposable pharmacokinetics in both serum and pancreatic juice.

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Year:  2008        PMID： 18809943      PMCID： PMC2573103          DOI： 10.1128/AAC.00509-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Authors:  J F Westphal; J M Brogard; F Caro-Sampara; M Adloff; J F Blicklé; H Monteil; F Jehl
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

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Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

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Review 5.  Piperacillin/tazobactam: an updated review of its use in the treatment of bacterial infections.

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Review 6.  Pharmacodynamics of antimicrobial therapy in surgery.

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7.  Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis.

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8.  Human pancreatic tissue concentration of bactericidal antibiotics.

Authors:  M Büchler; P Malfertheiner; H Friess; R Isenmann; E Vanek; H Grimm; P Schlegel; T Friess; H G Beger
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Authors:  Jean-Louis Frossard; Michael L Steer; Catherine M Pastor
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10.  Early antibiotic treatment in acute necrotising pancreatitis.

Authors:  V Sainio; E Kemppainen; P Puolakkainen; M Taavitsainen; L Kivisaari; V Valtonen; R Haapiainen; T Schröder; E Kivilaakso
Journal:  Lancet       Date:  1995-09-09       Impact factor: 79.321
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  1 in total

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