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Literature DB >> 18809938

In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus.

Karin Streker¹, Tina Schäfer, Christoph Freiberg, Heike Brötz-Oesterhelt, Jörg Hacker, Harald Labischinski, Knut Ohlsen.

Abstract

A conditional expression system has been developed using the isopropyl-beta-d-thiogalactopyranoside (IPTG)-inducible Pspac promoter to validate essential genes of Staphylococcus aureus in vivo. The system has been applied to prove the essentiality of ligA and to evaluate the function of tarI, which was found to be essential in vitro but not in vivo.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18809938 PMCID： PMC2592864 DOI： 10.1128/AAC.00548-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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Journal: Curr Opin Microbiol Date: 2004-10 Impact factor: 7.934

2. Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus.

Authors: F S Kaczmarek; R P Zaniewski; T D Gootz; D E Danley; M N Mansour; M Griffor; A V Kamath; M Cronan; J Mueller; D Sun; P K Martin; B Benton; L McDowell; D Biek; M B Schmid
Journal: J Bacteriol Date: 2001-05 Impact factor: 3.490

3. A method for demonstrating gene essentiality in Staphylococcus aureus.

Authors: M Jana; T T Luong; H Komatsuzawa; M Shigeta; C Y Lee
Journal: Plasmid Date: 2000-07 Impact factor: 3.466

4. Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors: M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
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5. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus.

Authors: R Novick
Journal: Virology Date: 1967-09 Impact factor: 3.616

6. Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway.

Authors: Michael A D'Elia; Mark P Pereira; Yu Seon Chung; Wenjun Zhao; Andrew Chau; Teresa J Kenney; Mark C Sulavik; Todd A Black; Eric D Brown
Journal: J Bacteriol Date: 2006-06 Impact factor: 3.490

7. Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection.

Authors: Jagath L Kadurugamuwa; Lin V Sin; Jun Yu; Kevin P Francis; Richard Kimura; Tony Purchio; Pamela R Contag
Journal: Antimicrob Agents Chemother Date: 2003-10 Impact factor: 5.191

8. Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.

Authors: Natalya E Voynova; Sandra E Rios; Henry M Miziorko
Journal: J Bacteriol Date: 2004-01 Impact factor: 3.490

9. Direct continuous method for monitoring biofilm infection in a mouse model.

Authors: Jagath L Kadurugamuwa; Lin Sin; Eddie Albert; Jun Yu; Kevin Francis; Monica DeBoer; Michael Rubin; Carole Bellinger-Kawahara; T R Parr; Pamela R Contag
Journal: Infect Immun Date: 2003-02 Impact factor: 3.441

10. A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.

Authors: Magdalena Zalacain; Sanjoy Biswas; Karen A Ingraham; Jennifer Ambrad; Alexander Bryant; Alison F Chalker; Serban Iordanescu; Jing Fan; Frank Fan; R Dwayne Lunsford; Karen O'Dwyer; Leslie M Palmer; Chi So; Daniel Sylvester; Craig Volker; Patrick Warren; Damien McDevitt; James R Brown; David J Holmes; Martin K R Burnham
Journal: J Mol Microbiol Biotechnol Date: 2003

6 in total

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Authors: Steven Howard; Nader Amin; Andrew B Benowitz; Elisabetta Chiarparin; Haifeng Cui; Xiaodong Deng; Tom D Heightman; David J Holmes; Anna Hopkins; Jianzhong Huang; Qi Jin; Constantine Kreatsoulas; Agnes C L Martin; Frances Massey; Lynn McCloskey; Paul N Mortenson; Puja Pathuri; Dominic Tisi; Pamela A Williams
Journal: ACS Med Chem Lett Date: 2013-10-18 Impact factor: 4.345

Review 2. Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads.

Authors: Coral González-Prieto; Cammie F Lesser
Journal: Curr Opin Microbiol Date: 2017-11-12 Impact factor: 7.934

3. Multiscale modelling of relationships between protein classes and drug behavior across all diseases using the CANDO platform.

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Journal: Mini Rev Med Chem Date: 2015 Impact factor: 3.862