Literature DB >> 18808135

The first synthesis of a thioglycoside analogue of the immunostimulant KRN7000.

Ravindra T Dere1, Xiangming Zhu.   

Abstract

The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18808135     DOI: 10.1021/ol8019555

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  5 in total

1.  Synthesis and Biological Activities of 5-Thio-α-GalCers.

Authors:  Jingjing Bi; Jing Wang; Kai Zhou; Yuancheng Wang; Min Fang; Yuguo Du
Journal:  ACS Med Chem Lett       Date:  2015-02-11       Impact factor: 4.345

Review 2.  Raising the roof: the preferential pharmacological stimulation of Th1 and th2 responses mediated by NKT cells.

Authors:  James E East; Andrew J Kennedy; Tonya J Webb
Journal:  Med Res Rev       Date:  2012-12-13       Impact factor: 12.944

3.  A Solvent-free Approach to Glycosyl Amides: Towards the Synthesis of α-N-Galactosyl Ceramides.

Authors:  Divya Chennamadhavuni; Amy R Howell
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

Review 4.  Stimulation of natural killer T cells by glycolipids.

Authors:  Brian L Anderson; Luc Teyton; Albert Bendelac; Paul B Savage
Journal:  Molecules       Date:  2013-12-16       Impact factor: 4.411

5.  Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation.

Authors:  Wayne Pilgrim; Ciaran O'Reilly; Paul V Murphy
Journal:  Molecules       Date:  2013-09-12       Impact factor: 4.411

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.