L Khorasani1, R P Kapur, C Lee, A M Avellino. 1. Division of Pediatric Neurosurgery, Children's Hospital and Regional Medical Center, Seattle, WA, USA.
Abstract
OBJECT: DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported. MATERIAL AND METHOD: We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty. CONCLUSION: Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.
OBJECT: DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported. MATERIAL AND METHOD: We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty. CONCLUSION: Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.
Authors: Kevin M Lewis; Jenifer Sweet; Scott T Wilson; Serge Rousselle; Heinz Gulle; Bernhard Baumgartner Journal: Neurosurgery Date: 2018-03-01 Impact factor: 4.654