Literature DB >> 18807240

[Stem cells--cloning, plasticity, bioethic].

Pamina Pflegerl1, Thomas Keller, Brigitte Hantusch, Thomas Sören Hoffmann, Lukas Kenner.   

Abstract

Stem cells with certain characteristics have become promising tools for molecular medicine. They have the potential to self-regenerate and to differentiate into specific tissues. Besides their great potential, embryonic stem cells (ESC) run the risk of enhanced tumorigenesis. The use of human embryonic stem cells (hESC) is ethically problematic because their isolation involves the destruction of human embryos. Recently developed methods generate are able to pluripotent stem cells from fibroblasts. Alternatives for ESC are adult stem cells (ASC) derived from bone marrow, cord blood, amniotic fluid and other tissues. The following article is on the basis of testimony of Lukas Kenner for the German Bundestag about the use of ESC for research, therapy and drug development. Ethical aspects are taken into consideration.

Entities:  

Mesh:

Year:  2008        PMID: 18807240     DOI: 10.1007/s10354-008-0551-x

Source DB:  PubMed          Journal:  Wien Med Wochenschr        ISSN: 0043-5341


  92 in total

1.  Human cells from cloned embryos in research and therapy.

Authors:  Ian Wilmut
Journal:  BMJ       Date:  2004-02-21

2.  Gene expression and methylation patterns in cloned embryos.

Authors:  Christine Wrenzycki; Doris Herrmann; Claudia Gebert; Joseph W Carnwath; Heiner Niemann
Journal:  Methods Mol Biol       Date:  2006

3.  Pluripotency redux--advances in stem-cell research.

Authors:  John Gearhart; Evanthia E Pashos; Megana K Prasad
Journal:  N Engl J Med       Date:  2007-10-11       Impact factor: 91.245

4.  Hematopoietic-cell transplantation at 50.

Authors:  Frederick R Appelbaum
Journal:  N Engl J Med       Date:  2007-10-11       Impact factor: 91.245

5.  Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

Authors:  Fyodor D Urnov; Jeffrey C Miller; Ya-Li Lee; Christian M Beausejour; Jeremy M Rock; Sheldon Augustus; Andrew C Jamieson; Matthew H Porteus; Philip D Gregory; Michael C Holmes
Journal:  Nature       Date:  2005-04-03       Impact factor: 49.962

6.  Contribution of human embryonic stem cells to mouse blastocysts.

Authors:  Daylon James; Scott A Noggle; Tomasz Swigut; Ali H Brivanlou
Journal:  Dev Biol       Date:  2006-07-01       Impact factor: 3.582

Review 7.  Modulating gene expression in stem cells without recombinant DNA and permanent genetic modification.

Authors:  Boon Chin Heng; Yun Han Hong; Tong Cao
Journal:  Cell Tissue Res       Date:  2005-06-08       Impact factor: 5.249

8.  Functional integration of embryonic stem cell-derived neurons in vivo.

Authors:  Marius Wernig; Felix Benninger; Tanja Schmandt; Monika Rade; Kerry L Tucker; Heinrich Büssow; Heinz Beck; Oliver Brüstle
Journal:  J Neurosci       Date:  2004-06-02       Impact factor: 6.167

9.  In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors:  Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin.

Authors:  L Denner; Y Bodenburg; J G Zhao; M Howe; J Cappo; R G Tilton; J A Copland; N Forraz; C McGuckin; R Urban
Journal:  Cell Prolif       Date:  2007-06       Impact factor: 6.831

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  1 in total

1.  Stem cell therapy for amyotrophic lateral sclerosis.

Authors:  Zhijuan Mao; Suming Zhang; Hong Chen
Journal:  Cell Regen       Date:  2015-11-19
  1 in total

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