| Literature DB >> 18805699 |
Elisa S C Pôças1, Natália A Touza, Paulo H C Pimenta, Fernanda B Leitão, Chaquip D Neto, Alcides J M da Silva, Paulo R R Costa, François Noël.
Abstract
The molecular mechanisms involved in Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan were investigated. We show that this compound decreases the free sulfydryl groups present in the enzyme and that its inhibitory effect is prevented by dithiothreitol and other two sulfydryl containing reagents. We propose a redox cycle culminating with the irreversible oxidation of sulfydryl groups essential for the catalytic activity of this enzyme and of two other related P-type ATPases.Entities:
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Year: 2008 PMID： 18805699 DOI： 10.1016/j.bmc.2008.09.007
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641