BACKGROUND: Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins. AIMS: To compare prenatal and neonatal discordances of head size in monozygotic-monochorionic (MZ-MC), monozygotic-dichorionic (MZ-DC), and same-sex dizygotic-dichorionic twin pairs (DZ). STUDY DESIGN: Subjects prospectively had ultrasounds at 22 and 32 weeks gestational age, and magnetic resonance imaging (MRI) of the brain MRI after birth. SUBJECTS: 88 twin pairs recruited from two university hospital prenatal diagnostic clinics; 22 MZ-MC, 17 MZ-DC, and 49 same-sex DZ pairs. OUTCOME MEASURES: Discordance of head circumference (HC) and weight at 22 weeks, 32 weeks and birth, as well as intracranial volume (ICV) on neonatal MRI. RESULTS: There were no group differences in discordance of head circumference and weight on the 22 or 32 week ultrasounds, or at birth. MZ-MC twins tended to have numerically greater discordances of HC and weight. There was a significant group difference in ICV on neonatal MRI (ANOVA, p=0.0143), with DZ twins having significantly greater discordance than MZ-MC (p=0.028) or MZ-DC (p=0.0131) twins. CONCLUSIONS: This study indicates that zygosity and chorionicity do not contribute to significant discordances of head size in late prenatal development. DZ twins do have significantly greater discordances of ICV on neonatal MRI, suggesting a relatively greater genetic influence on brain growth in the first weeks after birth.
BACKGROUND: Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins. AIMS: To compare prenatal and neonatal discordances of head size in monozygotic-monochorionic (MZ-MC), monozygotic-dichorionic (MZ-DC), and same-sex dizygotic-dichorionic twin pairs (DZ). STUDY DESIGN: Subjects prospectively had ultrasounds at 22 and 32 weeks gestational age, and magnetic resonance imaging (MRI) of the brain MRI after birth. SUBJECTS: 88 twin pairs recruited from two university hospital prenatal diagnostic clinics; 22 MZ-MC, 17 MZ-DC, and 49 same-sex DZ pairs. OUTCOME MEASURES: Discordance of head circumference (HC) and weight at 22 weeks, 32 weeks and birth, as well as intracranial volume (ICV) on neonatal MRI. RESULTS: There were no group differences in discordance of head circumference and weight on the 22 or 32 week ultrasounds, or at birth. MZ-MC twins tended to have numerically greater discordances of HC and weight. There was a significant group difference in ICV on neonatal MRI (ANOVA, p=0.0143), with DZ twins having significantly greater discordance than MZ-MC (p=0.028) or MZ-DC (p=0.0131) twins. CONCLUSIONS: This study indicates that zygosity and chorionicity do not contribute to significant discordances of head size in late prenatal development. DZ twins do have significantly greater discordances of ICV on neonatal MRI, suggesting a relatively greater genetic influence on brain growth in the first weeks after birth.
Authors: Vctor H González-Quintero; Barbara Luke; Mary J O'sullivan; Ruta Misiunas; Elaine Anderson; Clark Nugent; Frank Witter; Jill Mauldin; Roger Newman; Mary D'alton; David Grainger; George Saade; Gary Hankins; George Macones Journal: Am J Obstet Gynecol Date: 2003-09 Impact factor: 8.661
Authors: Carl E G Bruder; Arkadiusz Piotrowski; Antoinet A C J Gijsbers; Robin Andersson; Stephen Erickson; Teresita Diaz de Ståhl; Uwe Menzel; Johanna Sandgren; Desiree von Tell; Andrzej Poplawski; Michael Crowley; Chiquito Crasto; E Christopher Partridge; Hemant Tiwari; David B Allison; Jan Komorowski; Gert-Jan B van Ommen; Dorret I Boomsma; Nancy L Pedersen; Johan T den Dunnen; Karin Wirdefeldt; Jan P Dumanski Journal: Am J Hum Genet Date: 2008-02-14 Impact factor: 11.025
Authors: Rebecca C Knickmeyer; Chaeryon Kang; Sandra Woolson; J Keith Smith; Robert M Hamer; Weili Lin; Guido Gerig; Martin Styner; John H Gilmore Journal: Twin Res Hum Genet Date: 2011-06 Impact factor: 1.587
Authors: John H Gilmore; James Eric Schmitt; Rebecca C Knickmeyer; Jeffrey K Smith; Weili Lin; Martin Styner; Guido Gerig; Michael C Neale Journal: Hum Brain Mapp Date: 2010-08 Impact factor: 5.038
Authors: Kristine Marceau; Minni T B McMaster; Taylor F Smith; Joost G Daams; Catharina E M van Beijsterveldt; Dorret I Boomsma; Valerie S Knopik Journal: Behav Genet Date: 2016-03-05 Impact factor: 2.805