Literature DB >> 18804431

Endoplasmic reticulum stress, PrP trafficking, and neurodegeneration.

Claudio Soto1.   

Abstract

In this issue of Developmental Cell, Rane et al. report a cellular pathway to link PrP(Sc), via ER stress and the activation of a preemptive quality control process, to neurodegeneration in a PrP-dependent manner. This pathway puts together several pieces in the puzzle of the relationship between PrP(Sc) and brain damage and may in part explain the mechanism of prion neurodegeneration.

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Year:  2008        PMID： 18804431      PMCID： PMC2613161          DOI： 10.1016/j.devcel.2008.09.001

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

Review 1.  Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

Authors:  Byron Caughey; Peter T Lansbury
Journal:  Annu Rev Neurosci       Date:  2003-04-09       Impact factor: 12.449

Review 2.  Unfolding the role of protein misfolding in neurodegenerative diseases.

Authors:  Claudio Soto
Journal:  Nat Rev Neurosci       Date:  2003-01       Impact factor: 34.870

Review 3.  ER stress and neurodegenerative diseases.

Authors:  D Lindholm; H Wootz; L Korhonen
Journal:  Cell Death Differ       Date:  2006-03       Impact factor: 15.828

4.  Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.

Authors:  Neena S Rane; Sang-Wook Kang; Oishee Chakrabarti; Lionel Feigenbaum; Ramanujan S Hegde
Journal:  Dev Cell       Date:  2008-09       Impact factor: 12.270

5.  Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.

Authors:  Jiyan Ma; Robert Wollmann; Susan Lindquist
Journal:  Science       Date:  2002-10-17       Impact factor: 47.728

6.  Cross-linking cellular prion protein triggers neuronal apoptosis in vivo.

Authors:  Laura Solforosi; Jose R Criado; Dorian B McGavern; Sebastian Wirz; Manuel Sánchez-Alavez; Shuei Sugama; Lorraine A DeGiorgio; Bruce T Volpe; Erika Wiseman; Gil Abalos; Eliezer Masliah; Donald Gilden; Michael B Oldstone; Bruno Conti; R Anthony Williamson
Journal:  Science       Date:  2004-01-29       Impact factor: 47.728

Review 7.  Stressing out the ER: a role of the unfolded protein response in prion-related disorders.

Authors:  Claudio A Hetz; Claudio Soto
Journal:  Curr Mol Med       Date:  2006-02       Impact factor: 2.222

8.  Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.

Authors:  Luana Fioriti; Sara Dossena; Leanne R Stewart; Richard S Stewart; David A Harris; Gianluigi Forloni; Roberto Chiesa
Journal:  J Biol Chem       Date:  2005-01-04       Impact factor: 5.157

9.  Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

Authors:  Giovanna Mallucci; Andrew Dickinson; Jacqueline Linehan; Peter-Christian Klöhn; Sebastian Brandner; John Collinge
Journal:  Science       Date:  2003-10-31       Impact factor: 47.728

10.  Accumulation of prion protein in the brain that is not associated with transmissible disease.

Authors:  Pedro Piccardo; Jean C Manson; Declan King; Bernardino Ghetti; Rona M Barron
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-06       Impact factor: 11.205
  10 in total
  2 in total

1.  Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells.

Authors:  Zaira E Arellano Anaya; Jimmy Savistchenko; Véronique Massonneau; Caroline Lacroux; Olivier Andréoletti; Didier Vilette
Journal:  J Biol Chem       Date:  2011-01-06       Impact factor: 5.157

2.  Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction.

Authors:  Elena Quaglio; Elena Restelli; Anna Garofoli; Sara Dossena; Ada De Luigi; Luigina Tagliavacca; Daniele Imperiale; Antonio Migheli; Mario Salmona; Roberto Sitia; Gianluigi Forloni; Roberto Chiesa
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240
  2 in total

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