Literature DB >> 18804403

Bag-1 proteins in oral squamous cell carcinoma.

Jemma Wood1, San San Lee, Angela Hague.   

Abstract

Bag-1 is an anti-apoptotic protein that exhibits altered expression in many malignancies, including oral squamous cell carcinoma. The bag-1 gene gives rise to different protein products with different subcellular localisations through alternative translational initiation sites. In oral squamous cell carcinoma, cytoplasmic expression has been associated with metastasis to regional lymph nodes and poor prognosis. In contrast, the longest Bag-1 isoform is nuclear and may regulate differentiation in oral epithelium. In this review, the functions of the three isoforms of Bag-1 expressed in oral epithelial cells are discussed in relation to their contribution to oral carcinogenesis.

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Year:  2008        PMID： 18804403     DOI： 10.1016/j.oraloncology.2008.07.013

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  8 in total

1.  Expression of BAG-1 and PARP-1 in precursor lesions and invasive cervical cancer associated with human papillomavirus (HPV).

Authors:  Marcela Kazue Hassumi-Fukasawa; Fabiana Alves Miranda-Camargo; Bruna Riedo Zanetti; Denise Faria Galano; Alfredo Ribeiro-Silva; Edson Garcia Soares
Journal:  Pathol Oncol Res       Date:  2012-03-28       Impact factor: 3.201

2.  Exome sequencing of oral squamous cell carcinoma in users of Arabian snuff reveals novel candidates for driver genes.

Authors:  Nezar Noor Al-Hebshi; Shiyong Li; Akram Thabet Nasher; Maged El-Setouhy; Rashad Alsanosi; Jan Blancato; Christopher Loffredo
Journal:  Int J Cancer       Date:  2016-03-18       Impact factor: 7.396

3.  The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling.

Authors:  Anastasia Mashukova; Zhanna Kozhekbaeva; Radia Forteza; Vipin Dulam; Yolanda Figueroa; Robert Warren; Pedro J Salas
Journal:  J Cell Sci       Date:  2014-05-29       Impact factor: 5.285

4.  Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis.

Authors:  J Wood; M Pring; J W Eveson; N Price; C M Proby; A Hague
Journal:  Br J Cancer       Date:  2011-04-26       Impact factor: 7.640

5.  BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.

Authors:  S L Southern; T J Collard; B C Urban; V R Skeen; H J Smartt; A Hague; F Oakley; P A Townsend; N D Perkins; C Paraskeva; A C Williams
Journal:  Oncogene       Date:  2011-10-03       Impact factor: 9.867

6.  The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.

Authors:  Tilman Heise; Venkatesh Kota; Alexander Brock; Amanda B Morris; Reycel M Rodriguez; Avery W Zierk; Philip H Howe; Gunhild Sommer
Journal:  Oncotarget       Date:  2016-05-17

7.  Over-expression of BAG-1 in head and neck squamous cell carcinomas (HNSCC) is associated with cisplatin-resistance.

Authors:  Shutong Liu; Bo Ren; Hang Gao; Suchan Liao; Ying-Xian Zhai; Shirong Li; Xue-Jin Su; Ping Jin; David Stroncek; Zhixiang Xu; Qinghua Zeng; Yulin Li
Journal:  J Transl Med       Date:  2017-09-06       Impact factor: 5.531

8.  G-quadruplex located in the 5'UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance.

Authors:  Rachel Jodoin; Julie C Carrier; Nathalie Rivard; Martin Bisaillon; Jean-Pierre Perreault
Journal:  Nucleic Acids Res       Date:  2019-11-04       Impact factor: 16.971
  8 in total

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