Literature DB >> 18804107

Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion.

Volker Senner1, Sabine Ratzinger, Sonja Mertsch, Susanne Grässel, Werner Paulus.   

Abstract

The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.

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Year:  2008        PMID： 18804107     DOI： 10.1016/j.febslet.2008.09.017

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Association of collagen architecture with glioblastoma patient survival.

Authors:  Kelli B Pointer; Paul A Clark; Alexandra B Schroeder; M Shahriar Salamat; Kevin W Eliceiri; John S Kuo
Journal:  J Neurosurg       Date:  2016-09-02       Impact factor: 5.115

2.  Heparan sulfate accumulation and perlecan/HSPG2 up-regulation in tumour tissue predict low relapse-free survival for patients with glioblastoma.

Authors:  Galina M Kazanskaya; Alexandra Y Tsidulko; Alexander M Volkov; Roman S Kiselev; Anastasia V Suhovskih; Vyacheslav V Kobozev; Alexei S Gaytan; Svetlana V Aidagulova; Alexei L Krivoshapkin; Elvira V Grigorieva
Journal:  Histochem Cell Biol       Date:  2018-01-10       Impact factor: 4.304

Review 3.  The pathobiology of collagens in glioma.

Authors:  Leo S Payne; Paul H Huang
Journal:  Mol Cancer Res       Date:  2013-07-16       Impact factor: 5.852

4.  Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells.

Authors:  Stefan Rieken; Daniel Habermehl; Angela Mohr; Lena Wuerth; Katja Lindel; Klaus Weber; Jürgen Debus; Stephanie E Combs
Journal:  Radiat Oncol       Date:  2011-10-06       Impact factor: 3.481

5.  Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.

Authors:  Yangyang Xu; Lin Zhang; Yuzhen Wei; Xin Zhang; Ran Xu; Mingzhi Han; Bing Huang; Anjing Chen; Wenjie Li; Qing Zhang; Gang Li; Jian Wang; Peng Zhao; Xingang Li
Journal:  Oncotarget       Date:  2017-04-04

6.  Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.

Authors:  Felicitas Merz; Frank Gaunitz; Faramarz Dehghani; Christof Renner; Jürgen Meixensberger; Angelika Gutenberg; Alf Giese; Kosta Schopow; Christian Hellwig; Michael Schäfer; Manfred Bauer; Horst Stöcker; Gisela Taucher-Scholz; Marco Durante; Ingo Bechmann
Journal:  Neuro Oncol       Date:  2013-04-10       Impact factor: 12.300

7.  Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma.

Authors:  Konstanze B Bedal; Susanne Grässel; Peter J Oefner; Joerg Reinders; Torsten E Reichert; Richard Bauer
Journal:  PLoS One       Date:  2014-01-23       Impact factor: 3.240

8.  Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance.

Authors:  M M Gerlach; F Merz; G Wichmann; C Kubick; C Wittekind; F Lordick; A Dietz; I Bechmann
Journal:  Br J Cancer       Date:  2013-11-21       Impact factor: 7.640

9.  A PTEN-COL17A1 fusion gene and its novel regulatory role in Collagen XVII expression and GBM malignance.

Authors:  Xiaoyan Yan; Chuanbao Zhang; Tingyu Liang; Fan Yang; Haoyuan Wang; Fan Wu; Wen Wang; Zheng Wang; Wen Cheng; Jiangnan Xu; Tao Jiang; Jing Chen; Yaozhong Ding
Journal:  Oncotarget       Date:  2017-08-24

10.  Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma.

Authors:  Shen Sun; Yue Wang; Yue Wu; Yue Gao; Qi Li; Ayanlaja Abiola Abdulrahman; Xin-Feng Liu; Guang-Quan Ji; Jin Gao; Li Li; Fa-Ping Wan; Yun-Qing Li; Dian-Shuai Gao
Journal:  Int J Oncol       Date:  2018-09-21       Impact factor: 5.650
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